6-氯-9-(四氢-2-吡喃基)嘌呤合成路线 （共 29 条）
反应条件
toluene-4-sulfonic acid in ethyl acetate T=90°C; 1 h;
参考文献
AMGEN INC.
Patent: WO2008/153947 A2, 2008 ;
Location in patent: Page/Page column 41; 61 ;
WO 2008/153947 A2
反应条件
p-toluenesulfonic acid monohydrate
参考文献
Ortho Pharmaceutical Corporation
Patent: US4876257 A1, 1989 ;
Title/Abstract Full Text Show Details
Ortho Pharmaceutical Corporation
Patent: US5164390 A1, 1992 ;
反应条件
1: 86 percent / POCl3 / N,N-dimethyl-acetamide / 2 h / 120 °C 2: 68 percent / p-TsOH / tetrahydrofuran / 80 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 2, # 5 p. 665 - 670
参考文献
US2008/9508 A1, ;
Page/Page column 8 ;
反应条件
1.1: n-BuLi; 2,2,6,6-tetramethylpiperidine / hexane; tetrahydrofuran / 0.5 h / -78 °C 1.2: Bu3SnCl / hexane; tetrahydrofuran / 1 h / -78 °C 1.3: 8.0 g / iodine / tetrahydrofuran / 24 h 2.1: 98 percent / CuCl2 / aq. ethanol / 5 h / 85 °C 3.1: Ph3P / tetrahydrofuran / -30 °C View Scheme
参考文献
Brun, Virginie; Legraverend, Michel; Grierson, David S
Tetrahedron, 2002 , vol. 58, # 39 p. 7911 - 7923
反应条件
1: 84 percent / DABCO / acetonitrile / Ambient temperature 2: 95 percent / Dowex 50X8 (H+), H2O / methanol / 1 h / Heating View Scheme
参考文献
Hocek, Michal; Holy, Antonin
Collection of Czechoslovak Chemical Communications, 1995 , vol. 60, # 8 p. 1386 - 1389
反应条件
1.1: n-butyllithium / tetrahydrofuran / 2 h / Heating 1.2: 79 percent / aq. sodium carbonate / tetrahydrofuran / 3 h / Heating 2.1: 96 percent / Dowex 50W-X8 (H+) resin; aq. ammonium hydroxide / methanol View Scheme
参考文献
Hassan; Abou-Elkair; Montgomery; Secrist III
Nucleosides, Nucleotides and Nucleic Acids, 2000 , vol. 19, # 7 p. 1123 - 1134
反应条件
1: 78 percent / Et3N / Pd(PPh3)4; CuI / dimethylformamide / 7 h / 120 °C 2: 70 percent / NH3 / ethanol / 3 h / 20 °C View Scheme
参考文献
Hocek, Michal; Stara, Irena G.; Stary, Ivo; Dvorakova, Hana
Collection of Czechoslovak Chemical Communications, 2002 , vol. 67, # 8 p. 1223 - 1235
反应条件
chloro-trimethyl-silane; trimethylsilyl trifluoromethanesulfonate; 1,1,1,3,3,3-hexamethyl-disilazane in acetonitrile 4 h; Heating;
参考文献
Manfredini, Stefano; Baraldi, Pier Giovanni; Bazzanini, Rita; Guarneri, Mario; Simoni, Daniele
Journal of the Chemical Society, Chemical Communications, 1994 , # 5 p. 583 - 584
