ammonium hydroxide 0.5 h; Ambient temperature;

1: 75 percent / LiOH, H2O / tetrahydrofuran / 5 h / Ambient temperature 2: NH4OH / H2O / 0.5 h / Ambient temperature View Scheme

1: 98 percent / H2 / PtO2 / methanol / 3 h 2: 89 percent / concd. HCl, aq. NaNO2 / 0.33 h / 0 °C 3: HOAc, 50percent aq. H3PO2 / 1 h / Ambient temperature 4: 89 percent / aq. LiOH / tetrahydrofuran / 6.5 h 5: 68 percent / aq. NH4OH / 0.5 h View Scheme

1: 62 percent / H2, HCl / 10percent Pd/C / methanol 2: 60 percent / AgO, HNO3 / tetrahydrofuran / 0.17 h / Ambient temperature 3: 75 percent / LiOH, H2O / tetrahydrofuran / 5 h / Ambient temperature 4: NH4OH / H2O / 0.5 h / Ambient temperature View Scheme

1: Br2 / CH2Cl2 / Heating 2: Et3N / diethyl ether / 20 h / 25 °C 3: CH2Cl2 / 7 h / 25 °C 4: dry hydrogen chloride / CH2Cl2 / 10 h 5: 60 percent / ceric ammonium nitrate / acetonitrile; H2O / 0.17 h / 0 °C 6: 92 percent / p-tuluenesulfonic acid / methanol / 4 h / Heating 7: 98 percent / 0.5 M K2CO3 / H2O / 4 h / 85 °C 8: NH4OH / H2O / 30 h / 23 °C View Scheme

1: Et3N / diethyl ether / 20 h / 25 °C 2: CH2Cl2 / 7 h / 25 °C 3: dry hydrogen chloride / CH2Cl2 / 10 h 4: 60 percent / ceric ammonium nitrate / acetonitrile; H2O / 0.17 h / 0 °C 5: 92 percent / p-tuluenesulfonic acid / methanol / 4 h / Heating 6: 98 percent / 0.5 M K2CO3 / H2O / 4 h / 85 °C 7: NH4OH / H2O / 30 h / 23 °C View Scheme

1: 79 percent / hydrochloric acid / acetone; H2O / 1 h / Heating 2: CH2Cl2 / 7 h / 25 °C 3: dry hydrogen chloride / CH2Cl2 / 10 h 4: 60 percent / ceric ammonium nitrate / acetonitrile; H2O / 0.17 h / 0 °C 5: 92 percent / p-tuluenesulfonic acid / methanol / 4 h / Heating 6: 98 percent / 0.5 M K2CO3 / H2O / 4 h / 85 °C 7: NH4OH / H2O / 30 h / 23 °C View Scheme

1: dry hydrogen chloride / CH2Cl2 / 10 h 2: 60 percent / ceric ammonium nitrate / acetonitrile; H2O / 0.17 h / 0 °C 3: 92 percent / p-tuluenesulfonic acid / methanol / 4 h / Heating 4: 98 percent / 0.5 M K2CO3 / H2O / 4 h / 85 °C 5: NH4OH / H2O / 30 h / 23 °C View Scheme

1: 98 percent / 0.5 M K2CO3 / H2O / 4 h / 85 °C 2: NH4OH / H2O / 30 h / 23 °C View Scheme

1: CH2Cl2 / 7 h / 25 °C 2: dry hydrogen chloride / CH2Cl2 / 10 h 3: 60 percent / ceric ammonium nitrate / acetonitrile; H2O / 0.17 h / 0 °C 4: 92 percent / p-tuluenesulfonic acid / methanol / 4 h / Heating 5: 98 percent / 0.5 M K2CO3 / H2O / 4 h / 85 °C 6: NH4OH / H2O / 30 h / 23 °C View Scheme