(R)-3-氨基-3-(4-羟基苯基)丙酸合成路线 （共 8 条）
反应条件
sodium carbonate in acetone T=0°C; 2 h;
参考文献
Cardillo, Giuliana; Gentilucci, Luca; Melchiorre, Paolo; Spampinato, Santi
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2755 - 2758
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; 15 h;
参考文献
Davies, Stephen G.; Mulvaney, Andrew W.; Russell, Angela J.; Smith, Andrew D.
Tetrahedron Asymmetry, 2007 , vol. 18, # 13 p. 1554 - 1566
反应条件
penicillin G acylase; Eupergit in methanol
T=20°C; pH=7;
参考文献
Cardillo, Giuliana; Gentilucci, Luca; Melchiorre, Paolo; Spampinato, Santi
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2755 - 2758
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: 93 percent / tetrahydrofuran; hexane / 3 h / -78 °C
2.1: 81 percent / H2; acetic acid / Pd(OH)2/C / methanol; H2O / 24 h / 20 °C / 760.05 Torr
3.1: 94 percent / trifluoroacetic acid / CH2Cl2 / 15 h / 20 °C
View Scheme
参考文献
Davies, Stephen G.; Mulvaney, Andrew W.; Russell, Angela J.; Smith, Andrew D.
Tetrahedron Asymmetry, 2007 , vol. 18, # 13 p. 1554 - 1566
反应条件
1: 81 percent / H2; acetic acid / Pd(OH)2/C / methanol; H2O / 24 h / 20 °C / 760.05 Torr
2: 94 percent / trifluoroacetic acid / CH2Cl2 / 15 h / 20 °C
View Scheme
参考文献
Davies, Stephen G.; Mulvaney, Andrew W.; Russell, Angela J.; Smith, Andrew D.
Tetrahedron Asymmetry, 2007 , vol. 18, # 13 p. 1554 - 1566
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: 96 percent / tetrahydrofuran; hexane / -78 - 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: 93 percent / tetrahydrofuran; hexane / 3 h / -78 °C
3.1: 81 percent / H2; acetic acid / Pd(OH)2/C / methanol; H2O / 24 h / 20 °C / 760.05 Torr
4.1: 94 percent / trifluoroacetic acid / CH2Cl2 / 15 h / 20 °C
View Scheme
参考文献
Davies, Stephen G.; Mulvaney, Andrew W.; Russell, Angela J.; Smith, Andrew D.
Tetrahedron Asymmetry, 2007 , vol. 18, # 13 p. 1554 - 1566
反应条件
1: 75 percent / Et3N / acetone; H2O / 2 h / 0 °C
2: penicillin G acylase/eupergit; aq. buffer / methanol / 20 °C / pH 7
View Scheme
参考文献
Cardillo, Giuliana; Gentilucci, Luca; Melchiorre, Paolo; Spampinato, Santi
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2755 - 2758
反应条件
1: AcONH4 / ethanol / 6 h / Heating
2: 75 percent / Et3N / acetone; H2O / 2 h / 0 °C
3: penicillin G acylase/eupergit; aq. buffer / methanol / 20 °C / pH 7
View Scheme
参考文献
Cardillo, Giuliana; Gentilucci, Luca; Melchiorre, Paolo; Spampinato, Santi
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2755 - 2758
