4-甲氧基-n-(4-硝基苯基)苯胺合成路线 （共 17 条）
反应条件
ammonium chloride; water; zinc
参考文献
Li, Jie; Pei, Shuchen; Zhu, Yingxi; Wu, Jianbo; Chen, Yin; Zhang, Weiyu; Wu, Yong
Letters in Drug Design and Discovery, 2012 , vol. 9, # 4 p. 379 - 388
反应条件
caesium carbonate; P(i-BuNCH2)3CMe; tris(dibenzylideneacetone)dipalladium (0) in toluene
T=110°C; Buchwald-Hartwig amination reaction; 24 h;
参考文献
Iowa State University Research Foundation, Inc.
Patent: US7385058 B1, 2008 ;
Location in patent: Page/Page column 27-30; 35 ;
反应条件
tris(dibenzylideneacetone)dipalladium (0); BICMAP; caesium carbonate in toluene
T=100°C; Hartwig-Buchwald amination; 18 h; Inert atmosphere;
参考文献
Mino, Takashi; Naruse, Yoshiaki; Kobayashi, Shohei; Oishi, Shunsuke; Sakamoto, Masami; Fujita, Tsutomu
Tetrahedron Letters, 2009 , vol. 50, # 19 p. 2239 - 2241
反应条件
potassium phosphate; biphenyl-2-yl-di-tert-butyl-phosphane; tris(dibenzylideneacetone)dipalladium (0) in ethylene glycol dimethyl ether
T=80°C; Arylation; 16 h;
参考文献
Wolfe, John P.; Tomori, Hiroshi; Sadighi, Joseph P.; Yin, Jingjun; Buchwald, Stephen L.
Journal of Organic Chemistry, 2000 , vol. 65, # 4 p. 1158 - 1174
反应条件
triethylamine in N,N-dimethyl-formamide
T=30°C; P=11250900 Torr; 72 h;
参考文献
Brown, Christopher L.; Muderawan, I. Wayan; Young, David J.
Synthesis, 2003 , # 16 p. 2511 - 2517
反应条件
formic acid; potassium methanolate in methanol; anhydrous xylene; n-heptane; toluene
参考文献
Monsanto Company
Patent: US4187248 A1, 1980 ;
反应条件
1: With caesium carbonate; chloroacetyl chloride in N,N-dimethyl-formamide
T=20°C; Smiles rearrangement; 0.5 h;
2: in N,N-dimethyl-formamide
T=150°C; Smiles rearrangement; Microwave irradiation;
参考文献
Tian, Xiao; Wu, Ren-Min; Liu, Gang; Li, Zhu-Bo; Wei, He-Lin; Yang, Hao; Shin, Dong-Soo; Wang, Li-Ying; Zuo, Hua
Arkivoc, 2011 , vol. 2011, # 10 p. 118 - 126
反应条件
1: in tetrahydrofuran
T=-20°C; 2 h;
2: With sodium tetrahydroborate; iron(II) chloride in tetrahydrofuran
T=-20 - 20°C; 2 h;
参考文献
Sapountzis, Ioannis; Knochel, Paul
Synlett, 2004 , # 6 p. 955 - 958
反应条件
selenium(IV) oxide; dihydrogen peroxide in methanol; water
T=20°C; 20 h;
参考文献
Gebhardt, Christin; Priewisch, Beate; Irran, Elisabeth; Rueck-Braun, Karola
Synthesis, 2008 , # 12 art. no. Z05208SS, p. 1889 - 1894
反应条件
potassium carbonate; potassium iodide in acetonitrile
Inert atmosphereReflux;
参考文献
Li, Jie; Pei, Shuchen; Zhu, Yingxi; Wu, Jianbo; Chen, Yin; Zhang, Weiyu; Wu, Yong
Letters in Drug Design and Discovery, 2012 , vol. 9, # 4 p. 379 - 388
