5-乙氧基甲基-2-甲基嘧啶-4-基胺合成路线 （共 15 条）
反应条件
hydrogenchloride; butan-1-ol
参考文献
Research Corp.
Patent: US2184964 , 1937 ;
反应条件
hydrogen bromide; acetic acid
参考文献
Cline et al.
Journal of the American Chemical Society, 1937 , vol. 59, p. 1052
反应条件
1: 2-methyl-4-amino-5-ethoxymethyl pyrimidine With hydrogenchloride in water T=90 - 95°C; Substitution; 5 h; 2: 4-methyl-5-thiazole ethanol T=102°C; Alkylation; 4 h;
参考文献
Litvak
Pharmaceutical Chemistry Journal, 1999 , vol. 33, # 2 p. 101 - 103
反应条件
ethanol; ammonia
T=140°C;
参考文献
Cline et al.
Journal of the American Chemical Society, 1937 , vol. 59, p. 1052
反应条件
1: POCl3
2: ethanol; NH3 / 140 °C
View Scheme
参考文献
Cline et al.
Journal of the American Chemical Society, 1937 , vol. 59, p. 1052
反应条件
ethanol
T=90 - 100°C;
参考文献
Hoffmann-La Roche
Patent: US2480326 , 1946 ;
反应条件
1: ethyl formate; benzene / beim Erwaermen des Reaktionsgemisches mit Dimethylsulfat
2: ethanol
View Scheme
参考文献
Fodor et al.
Zhurnal Obshchei Khimii, 1951 , vol. 21, p. 1897,1900; engl. Ausg. S. 2109, 2111
Show Details
Takamizawa et al.
Yakugaku Zasshi, 1958 , vol. 78, p. 637,642
Chemical and Pharmaceutical Bulletin, 1966 , vol. 14, p. 238
Chem.Abstr., 1958 , p. 18411
参考文献
Fodor et al.
Zhurnal Obshchei Khimii, 1951 , vol. 21, p. 1897,1900; engl. Ausg. S. 2109, 2111
Show Details
Takamizawa et al.
Yakugaku Zasshi, 1958 , vol. 78, p. 637,642
Chemical and Pharmaceutical Bulletin, 1966 , vol. 14, p. 238
Chem.Abstr., 1958 , p. 18411
参考文献
Fodor et al.
Zhurnal Obshchei Khimii, 1951 , vol. 21, p. 1897,1900; engl. Ausg. S. 2109, 2111
Show Details
Takamizawa et al.
Yakugaku Zasshi, 1958 , vol. 78, p. 637,642
Chemical and Pharmaceutical Bulletin, 1966 , vol. 14, p. 238
Chem.Abstr., 1958 , p. 18411
参考文献
Tschelinzew; Benewolenskaja
Zhurnal Obshchei Khimii, 1944 , vol. 14, p. 1144
Chem.Abstr., 1946 , p. 4069
