5-氯-1,2,3,4-四氢喹啉合成路线 （共 4 条）
反应条件
1: With hydrogen; platinum(IV) oxide in acetic acid
T=20°C; 4 h;
2: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
ELI LILLY AND COMPANY
Patent: WO2003/76442 A1, 2003 ;
Location in patent: Page/Page column 23 ;
WO 03/076442 A1
反应条件
sodium tetrahydroborate in 1,4-dioxane
T=90°C; 0.5 h;
参考文献
Ishikawa; Tabusa; Miyamoto; Kano; Ueda; Tamaoka; Nakagawa
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 8 p. 2103 - 2108
反应条件
diisobutylaluminium hydride in hexane; dichloromethane
T=20°C; 3 h;
参考文献
Sakami, Satoshi; Kawai, Koji; Maeda, Masayuki; Aoki, Takumi; Fujii, Hideaki; Ohno, Hiroshi; Ito, Tsuyoshi; Saitoh, Akiyoshi; Nakao, Kaoru; Izumimoto, Naoki; Matsuura, Hirotoshi; Endo, Takashi; Ueno, Shinya; Natsume, Kazuto; Nagase, Hiroshi
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 17 p. 7956 - 7967
反应条件
1: 1.) NaNO2, 20percent HCl, 2.) CuCl, cc HCl, / 1.) H2O, RT; 1 h, 2.) 50 to 60 deg C, 1 h,
2: 72 percent / NaBH4, / dioxane / 0.5 h / 90 °C
View Scheme
参考文献
Ishikawa; Tabusa; Miyamoto; Kano; Ueda; Tamaoka; Nakagawa
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 8 p. 2103 - 2108
