2-羟基-5-乙酰氨基苯乙酮合成路线 （共 25 条）
反应条件
carbon disulfide; aluminium trichloride Irradiation;
参考文献
Chemische Berichte, , vol. 34, p. 125
反应条件
carbon disulfide; aluminium trichloride
参考文献
Chem. Zentralbl., , vol. 84, # II p. 2124
参考文献
Bulletin de la Societe Chimique de France, , p. 639
参考文献
Journal of the Chemical Society, , p. 1133,1136
参考文献
Elliott; Selnick; Claremon; Baldwin; Buhrow; Butcher; Habecker; King; Lynch Jr.; Phillips; Ponticello; Radzilowski; Remy; Stein; White; Young
Journal of Medicinal Chemistry, 1992 , vol. 35, # 21 p. 3973 - 3976
反应条件
hydrogenchloride; sodium hydroxide in methanol; ethanol; water
参考文献
Merck and Co., Inc.
Patent: US5206240 A1, 1993 ;
US 5206240 A
反应条件
1: sodium 2: acetic acid; concentrated aqueous hydrochloric acid / 120 °C View Scheme
参考文献
Moorkoth, Sudheer; Srinivasan; Gopalan Kutty; Joseph, Alex; Naseer
Medicinal Chemistry Research, 2013 , vol. 22, # 10 p. 5066 - 5075
反应条件
1: pyrrolidine / methanol / 25 °C 2: hydrogenchloride / ethanol / 3 h / Reflux View Scheme
参考文献
UNIVERSITE DE LIEGE; UNIVERSITE LIBRE DE BRUXELLES; GOFFIN, Eric; DE TULLIO, Pascal; FLORENCE, Xavier; PIROTTE, Bernard; ROGISTER, Bernard; LAMORAL-THEYS, Delphine; LEFRANC, Florence; KISS, Robert
Patent: WO2012/107262 A1, 2012 ;
反应条件
1: With sodium hydroxide in ethanol; water T=20°C; 6 h; 2: With acetic acid in ethanol; water 1 h; Cooling with ice;
参考文献
The University of Melbourne
Patent: US7863323 B1, 2011 ;
Location in patent: Page/Page column 17; 23; 24 ;
反应条件
1: 71 percent / nitric acid, glacial acetic acid / 2 h / Ambient temperature 2: 96 percent / methanol; H2O / 1 h / 85 °C 3: 90 percent / NaNO2, H2SO4 / ethanol; H2O / 1.) from 0 to 5 deg C, 20 min, 2.) 85 deg C, 20 min, 3.) RT, 1 h View Scheme
参考文献
Cushman, Mark; Zhu, Helen; Geahlen, Robert L.; Kraker, Alan J.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3353 - 3362
