1-(4-氯苯基)-1-己酮合成路线 （共 9 条）
反应条件
ammonium hydroxide; copper(l) chloride T=250 - 270°C;
参考文献
Nikolenko; Babiewskii
Zhurnal Obshchei Khimii, 1955 , vol. 25, p. 2231,2233
J. Gen. Chem. USSR (Engl. Transl.), 1955 , vol. 25, p. 2195,2196
反应条件
bromine in diethyl ether
参考文献
Imperial Chemical Industries PLC
Patent: US4472415 A1, 1984 ;
反应条件
sodium hydroxide; [{(η5-C5Me5)IrCl}2(μ-Cl)2] in toluene
T=110°C; 17 h;
参考文献
Fujita, Ken-Ichi; Asai, Chiho; Yamaguchi, Tetsuhiro; Hanasaka, Fumihiro; Yamaguchi, Ryohei
Organic Letters, 2005 , vol. 7, # 18 p. 4017 - 4019
反应条件
pyrrolidine; 1,3-bis-(diphenylphosphino)propane; bis(dibenzylideneacetone)-palladium(0) in N,N-dimethyl-formamide
T=115°C; Heck reaction; 6 h; Molecular sieve;
参考文献
Ruan, Jiwu; Saidi, Ourida; Iggo, Jonathan A.; Xiao, Jianliang
Journal of the American Chemical Society, 2008 , vol. 130, # 32 p. 10510 - 10511
反应条件
1: n-pentyltriphenylphosphonium bromide With n-butyllithium in tetrahydrofuran; hexane
T=-15°C;
2: 4-chloro-N-methoxy-N-methyl-benzamide in tetrahydrofuran; hexane
T=-78 - 20°C; Wittig reaction;
3: With hydrogenchloride in tetrahydrofuran; diethyl ether; hexane
T=20°C;
参考文献
Murphy, John A.; Commeureuc, Aurelien G. J.; Snaddon, Thomas N.; McGuire, Thomas M.; Khan, Tanweer A.; Hisler, Kevin; Dewis, Mark L.; Carling, Robert
Organic Letters, 2005 , vol. 7, # 7 p. 1427 - 1429
反应条件
[{(η5-C5Me5)IrCl}2(μ-Cl)2]; potassium hydroxide
T=110°C; Aldol Condensation; 0.166667 h; Inert atmosphere;
参考文献
Li, Jian; Zhang, Weixing; Wang, Feng; Jiang, Min; Dong, Xiaochun; Zhao, Weili
Chinese Journal of Chemistry, 2012 , vol. 30, # 10 p. 2363 - 2366,4
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; [Rh(OH)(cycloocta-1,5-diene)]2 in 1,4-dioxane; water
T=90°C; 12 h; Inert atmosphere;
参考文献
Shimizu, Hiroshi; Igarashi, Tomohiro; Miura, Tomoya; Murakami, Masahiro
Angewandte Chemie - International Edition, 2011 , vol. 50, # 48 p. 11465 - 11469
反应条件
1.1: 95 percent / tetrahydrofuran / 3 h / -78 °C
2.1: n-BuLi / tetrahydrofuran; hexane / -15 °C
2.2: tetrahydrofuran; hexane / -78 - 20 °C
2.3: 83 percent / aq. HCl / tetrahydrofuran; hexane; diethyl ether / 20 °C
View Scheme
参考文献
Murphy, John A.; Commeureuc, Aurelien G. J.; Snaddon, Thomas N.; McGuire, Thomas M.; Khan, Tanweer A.; Hisler, Kevin; Dewis, Mark L.; Carling, Robert
Organic Letters, 2005 , vol. 7, # 7 p. 1427 - 1429
反应条件
carbon disulfide; aluminium trichloride
参考文献
Lutz et al.
Journal of Organic Chemistry, 1947 , vol. 12, p. 617,680
Show Details
Cavell; Sugden
Journal of the Chemical Society, 1935 , p. 621,624
