hydrogen; palladium on activated charcoal in tert-butyl alcohol 7 h;

1: 92.2 percent / N-methylmorpholine, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / CH2Cl2 / 22 h / 0 - 20 °C 2: 4 N HCl / dioxane / 1 h / Ambient temperature 3: N-methylmorpholine, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / CH2Cl2 / 22 h / 0 - 20 °C 4: 90 percent / H2 / 10percent Pd/C / 2-methyl-propan-2-ol / 7 h View Scheme

1: 92.2 percent / N-methylmorpholine, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / CH2Cl2 / 22 h / 0 - 20 °C 2: 4 N HCl / dioxane / 1 h / Ambient temperature 3: N-methylmorpholine, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / CH2Cl2 / 22 h / 0 - 20 °C 4: 90 percent / H2 / 10percent Pd/C / 2-methyl-propan-2-ol / 7 h View Scheme

1: 4 N HCl / dioxane / 1 h / Ambient temperature 2: N-methylmorpholine, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / CH2Cl2 / 22 h / 0 - 20 °C 3: 90 percent / H2 / 10percent Pd/C / 2-methyl-propan-2-ol / 7 h View Scheme

1: N-methylmorpholine, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / CH2Cl2 / 22 h / 0 - 20 °C 2: 90 percent / H2 / 10percent Pd/C / 2-methyl-propan-2-ol / 7 h View Scheme