反应条件
1: oxalyl chloride, DMF / CH2Cl2 2: 1.) n-BuLi / 1.) hexane, RT, 5 min, 2.) THF, hexane, RT, overnight 3: H2 / 10percent Pd/C / tetrahydrofuran / 0.5 h / 2068.6 Torr 4: sodium cyanoborohydride, acetic acid / methanol 5: TFA, triethylsilane / CH2Cl2 / 1 h / Ambient temperature View Scheme
参考文献
Qian, Yimin; Vogt, Andreas; Sebti, Said M.; Hamilton, Andrew D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 217 - 223
