1-(2-甲基苯基)乙醇合成路线 （共 64 条）
反应条件
potassium tert-butylate; hydrogen; triphenylphosphine in toluene; tert-butyl alcohol T=25°C; P=15201 Torr; 8 h; Product distribution / selectivity;
参考文献
Sandoval, Christian A.; Li, Yue-hui
Patent: US2011/92712 A1, 2011 ;
Location in patent: Page/Page column 8; 9 ;
反应条件
1: With titanium(IV) isopropylate; (Sa)-2'-[(R)-hydroxy(phenyl)methyl]-(1,1'-binaphthalen)-2-ol in diethyl ether; toluene T=0°C; 1 h; Inert atmosphere; 2: With hydrogenchloride in diethyl ether; water; toluene Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Fernandez-Mateos, Emilio; MacIa, Beatriz; Yus, Miguel
Tetrahedron Asymmetry, 2012 , vol. 23, # 10 p. 789 - 794
反应条件
(1R)-N-oxyl-1-(N-benzylcarbamoyl)-8-azabicyclo[3.2.1]octane; sodium hydrogencarbonate; sodium bromide in dichloromethane; water T=0°C; Electrochemical reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Demizu, Yosuke; Shiigi, Hirofumi; Mori, Hiroyuki; Matsumoto, Kazuya; Onomura, Osamu
Tetrahedron Asymmetry, 2008 , vol. 19, # 23 p. 2659 - 2665
反应条件
1: With benzo[1,3,2]dioxaborole; rhodium complex 2 in toluene T=20°C; Addition; Hydroboration; 2 h; 2: With sodium hydroxide; water; dihydrogen peroxide in toluene T=20°C; Oxidation; 2 h; Title compound not separated from byproducts;
参考文献
Chemistry - A European Journal, , vol. 5, # 4 p. 1320 - 1330
反应条件
n-butyllithium; polymethylhydrosiloxane; chiral titanocene 1,1'-binaphth-2,2'-diolate; tetrabutyl ammonium fluoride 1.) benzene, hexane, 1 d, 2.) benzene, hexane, THF; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 116, # 26 p. 11667 - 11670
反应条件
chiral 2-(3',5'-di-tert-butylphenyl)-4,4,8-trimethyl-2-phosphabicyclolt;3.3.0gt;octane in n-heptane T=-40°C; 4 h; Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 121, # 24 p. 5813 - 5814
反应条件
sodium hydrogencarbonate; sodium bromide; chiral azabicyclo-N-oxyl in dichloromethane T=0°C; Electrochemical reaction;
参考文献
Tetrahedron Letters, , vol. 49, # 36 p. 5247 - 5251
反应条件
1H-imidazole; chloro{tetrasodium-5,10,15,20-tetrakis[(1S,4R,5R,8S)-10-sulfonato-1,2,3,4,5,6,7,8-octahydro-1,4:5,8-dimethanoanthracene-9-yl]porphyrin} manganese(III); dihydrogen peroxide in methanol T=25°C; pH=7; Inert atmosphereaq. phosphate buffer; optical yield given as percent eeenantioselective reaction;
参考文献
Inorganic Chemistry, , vol. 51, # 10 p. 5850 - 5856
反应条件
(S)-1-benzyl-3-(Ph2CH)NH-piperidine in tetrahydrofuran T=-78°C; 1 h; Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 58, # 23 p. 4707 - 4716
反应条件
(R)-5-CF3-2-Ph-2,3-dihydroimidazo[1,2-a]pyridine; N-ethyl-N,N-diisopropylamine in chloroform 8 h; cooling; Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 126, # 39 p. 12226 - 12227
