2-氧代-4-(三氟甲基)-2,3-二氢-1,3-噻唑-5-甲醛合成路线 （共 10 条）
反应条件
in chlorobenzene T=135°C; 2 h;
参考文献
Lee, Len F.; Schleppnik, Francis M.; Howe, Robert K.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1621 - 1630
反应条件
in chlorobenzene 24 h; Heating;
参考文献
Liu, Chang-Ling; Li, Miao; Chi, Hui-Wei; Hou, Chun-Qing; Li, Zheng-Ming
Journal of Fluorine Chemistry, 2006 , vol. 127, # 6 p. 796 - 799
反应条件
in chlorobenzene 1.) 70 deg C, 17 h, 2.) 80 deg C, 2 h, 3.) 90 deg C, 2 h;; Yields of byproduct given;
参考文献
Lee, Len F.; Schleppnik, Francis M.; Howe, Robert K.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1621 - 1630
反应条件
1: 92 percent / POCl3 / Heating 2: 31 percent / NaBH4 / dimethylformamide / 0.33 h / 0 °C / exothermic reaction View Scheme
参考文献
Lee, Len F.; Schleppnik, Francis M.; Howe, Robert K.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1621 - 1630
反应条件
1: 92 percent / POCl3 / Heating 2: 73 percent / aq. NaOH / tetrahydrofuran / 16 h / Ambient temperature View Scheme
参考文献
Lee, Len F.; Schleppnik, Francis M.; Howe, Robert K.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1621 - 1630
反应条件
trichlorophosphate in N-methyl-acetamide; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; chlorobenzene; Petroleum ether
参考文献
Monsanto Company
Patent: US4199506 A1, 1980 ;
反应条件
trichlorophosphate Heating;
参考文献
Liu, Chang-Ling; Li, Miao; Chi, Hui-Wei; Hou, Chun-Qing; Li, Zheng-Ming
Journal of Fluorine Chemistry, 2006 , vol. 127, # 6 p. 796 - 799
反应条件
1: 92 percent / POCl3 / Heating 2: 73 percent / aq. NaOH / tetrahydrofuran / 16 h / Ambient temperature 3: 98 percent / SOCl2 / 6 h / Heating 4: 53 percent / 6 h / 130 - 140 °C View Scheme
参考文献
Lee, Len F.; Schleppnik, Francis M.; Howe, Robert K.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1621 - 1630
反应条件
1: 92 percent / POCl3 / Heating
2: 73 percent / aq. NaOH / tetrahydrofuran / 16 h / Ambient temperature
3: 98 percent / SOCl2 / 6 h / Heating
4: 95 percent / 6 h / Heating
View Scheme
参考文献
Lee, Len F.; Schleppnik, Francis M.; Howe, Robert K.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1621 - 1630
反应条件
1: With lithium hydroxide in tetrahydrofuran; water
T=50°C; 72 h;
2: With hydrogenchloride in water
T=20°C; pH=3;
参考文献
ASTRAZENECA AB
Patent: WO2005/73192 A1, 2005 ;
Location in patent: Page/Page column 28 ;
WO 2005/073192 A1
