3-(2,6-二氯苯基)-3-氧代丙酸乙酯合成路线 (共 2 条)
反应条件
sodium in ethanol T=150°C;
参考文献
Bloomfield, Derek G.; Upton, Christopher; Vipond, Hilton J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 857 - 860
反应条件
1: malonic acid ethyl ester monopotassium salt With triethylamine; magnesium chloride in acetonitrile T=10 - 15°C; 2.5 h; 2: 2,6-dichloro-1-benzenecarbonyl chloride in acetonitrile T=0 - 20°C;
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 22 p. 10090 - 10107