1-(5-氯-2-甲基苯基)-2-硫脲合成路线 （共 7 条）
反应条件
sulfuric acid in water; chlorobenzene
T=50 - 110°C;
参考文献
Amgen Inc.
Patent: US2005/250820 A1, 2005 ;
Location in patent: Page/Page column 41 ;
US 20050250820 A1
反应条件
sodium hydroxide
T=80 - 87°C; 0.133333 h;
参考文献
Rasmussen, C. R.; Villani, F. J.; Weaner, L. E.; Reynolds, B. E.; Hood, A. R.; et al.
Synthesis, 1988 , # 6 p. 456 - 459
反应条件
1: 92 percent / benzene / 2 - 3 h
2: 76 percent / 2,5 N NaOH / 0.5 h / 100 °C
View Scheme
参考文献
Gupta, K. A.; Saxena, Anil K.; Jain, Padam C.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 3 p. 228 - 233
参考文献
Browne; Dyson
Journal of the Chemical Society, 1931 , p. 3285,3299
反应条件
1: 2-methyl-5-chloroaniline With hydrogenchloride in water
0.5 h; Reflux;
2: ammonium thiocyanate in water
4 h; Reflux;
参考文献
Sharma, Praveen Kumar; Fogla, Ankur; Rathore; Kumar
Research on Chemical Intermediates, 2011 , vol. 37, # 8 p. 1103 - 1111
反应条件
1: 63 percent / methanol / Heating; 3 - 4 h
2: 42 percent / 20 h / 140 °C
View Scheme
参考文献
Gupta, K. A.; Saxena, Anil K.; Jain, Padam C.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 3 p. 228 - 233
反应条件
thionyl chloride
T=50 - 55°C; 4 h;
参考文献
Papenfuhs, Theodor
Angewandte Chemie, 1982 , vol. 94, # 7 p. 544
