2,2,2-三氯-1-(4-氯-1H-吡咯-2-基)乙酮合成路线 （共 6 条）
反应条件
1: With sodium hydroxide in tetrahydrofuran; water T=20°C; 1 h; 2: With hydrogenchloride in water pH=5;
参考文献
ADDEX PHARMACEUTICALS SA
Patent: WO2006/123257 A2, 2006 ;
Location in patent: Page/Page column 58 ;
WO 2006/123257 A2
反应条件
in methanol T=20°C; 1 h;
参考文献
AMBIT BIOSCIENCES CORPORATION; ABRAHAM, Sunny; CHAO, Qi; HADD. Michael, J.; HOLLADAY, Mark, W.; LIU, Gang; NAMBU, Mitchell, D.; SETTI, Eduardo
Patent: WO2010/2472 A1, 2010 ;
Location in patent: Page/Page column 168 ;
WO 2010/002472 A1
参考文献
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA
Patent: WO2007/138355 A1, 2007 ;
Location in patent: Page/Page column 89 ;
WO 2007/138355 A1
参考文献
Smith, Jason A.; Ng, Sarah; White, Jonathon
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 12 p. 2477 - 2482
反应条件
sulfuryl dichloride in chloroform
参考文献
Smith, Jason A.; Ng, Sarah; White, Jonathon
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 12 p. 2477 - 2482
反应条件
sulfuryl dichloride in chloroform
T=20°C; Cooling with ice;
参考文献
Clark, Benjamin R.; O'Connor, Stephen; Fox, Deirdre; Leroy, Jacques; Murphy, Cormac D.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 18 p. 6306 - 6311
