4-(4-甲氧基苯基)丁胺合成路线 （共 18 条）
反应条件
samarium diiodide in tetrahydrofuran; methanol 8 h; Ambient temperature;
参考文献
Tetrahedron Letters, , vol. 32, # 14 p. 1699 - 1702
反应条件
1: aq. ammonia / 0.5 h / 0 °C 2: 14 percent / LiAlH4 / CH2Cl2; tetrahydrofuran / 96 h / Heating View Scheme
参考文献
Archiv der Pharmazie, , vol. 331, # 12 p. 395 - 404
反应条件
hydrogen bromide
1 h; Heating;
参考文献
Yasunaga, Tomoyuki; Kimura, Takenori; Naito, Ryo; Kontani, Toru; Wanibuchi, Fumikazu; Yamashita, Hiroshi; Nomura, Tamako; Tsukamoto, Shin-Ichi; Yamaguchi, Tokio; Mase, Toshiyasu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 15 p. 2765 - 2778
反应条件
1: aq. NaHCO3 / CH2Cl2
2: LiAlH4 / tetrahydrofuran / Heating
View Scheme
参考文献
Yasunaga, Tomoyuki; Kimura, Takenori; Naito, Ryo; Kontani, Toru; Wanibuchi, Fumikazu; Yamashita, Hiroshi; Nomura, Tamako; Tsukamoto, Shin-Ichi; Yamaguchi, Tokio; Mase, Toshiyasu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 15 p. 2765 - 2778
反应条件
1: 90 percent / aq. HBr / 3 h / Heating
2: 62 percent / sodium bicarbonate / dioxane; H2O / -2 - 20 °C
View Scheme
参考文献
Hirsh, Andrew J.; Molino, Bruce F.; Zhang, Jianzhong; Astakhova, Nadezhda; Geiss, William B.; Sargent, Bruce J.; Swenson, Brian D.; Usyatinsky, Alexander; Wyle, Michael J.; Boucher, Richard C.; Smith, Rick T.; Zamurs, Andra; Johnson, M. Ross
Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4098 - 4115
反应条件
1: 90 percent / aq. HBr / 3 h / Heating
2: 62 percent / sodium bicarbonate / dioxane; H2O / -2 - 20 °C
3: 58 percent / triethylamine / ethanol / 2 h / Heating
View Scheme
参考文献
Hirsh, Andrew J.; Molino, Bruce F.; Zhang, Jianzhong; Astakhova, Nadezhda; Geiss, William B.; Sargent, Bruce J.; Swenson, Brian D.; Usyatinsky, Alexander; Wyle, Michael J.; Boucher, Richard C.; Smith, Rick T.; Zamurs, Andra; Johnson, M. Ross
Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4098 - 4115
反应条件
triethylamine in dichloromethane
2 h; Ambient temperature;
参考文献
Garratt, Peter J.; Travard, Sylvie; Vonhoff, Stefan; Tsotinis, Andrew; Sugden, David
Journal of Medicinal Chemistry, 1996 , vol. 39, # 9 p. 1796 - 1805
反应条件
triethylamine in dichloromethane
3 h; Ambient temperature;
参考文献
Ganellin, C. Robin; Leurquin, Fabien; Piripitsi, Antonia; Arrang, Jean-Michel; Garbarg, Monique; Ligneau, Xavier; Schunack, Walter; Schwartz, Jean-Charles
Archiv der Pharmazie, 1998 , vol. 331, # 12 p. 395 - 404
