4-(4-甲氧基苯基)丁胺合成路线 （共 18 条）
反应条件
water; triphenylphosphine in tetrahydrofuran T=20°C;
参考文献
Hirsh, Andrew J.; Molino, Bruce F.; Zhang, Jianzhong; Astakhova, Nadezhda; Geiss, William B.; Sargent, Bruce J.; Swenson, Brian D.; Usyatinsky, Alexander; Wyle, Michael J.; Boucher, Richard C.; Smith, Rick T.; Zamurs, Andra; Johnson, M. Ross
Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4098 - 4115
反应条件
in tetrahydrofuran; diethyl ether; water
参考文献
Larsen, Scott D.; May, Paul D.; Bleasdale, John E.; Liljebris, Charlotta; Schostarez, Heinrich Josef; Barf, Tjeerd; Nilsson, Marianne
Patent: US6410585 B1, 2002 ;
US 6410585 B1
反应条件
in tetrahydrofuran; diethyl ether; water
参考文献
Larsen, Scott D.; May, Paul D.; Bleasdale, John E.; Liljebris, Charlotta; Schostarez, Heinrich Josef; Barf, Tjeerd; Nilsson, Marianne
Patent: US6410585 B1, 2002 ;
US 6410585 B1
反应条件
1: H2 / 10percent Pd/C / dioxane; ethanol / 3 h / 760 Torr / Ambient temperature 2: MeNH2 / methanol / 14 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 15 p. 2765 - 2778
反应条件
1: NaOMe, MeOH / dioxane / 12 h / Ambient temperature 2: H2 / 10percent Pd/C / dioxane; ethanol / 3 h / 760 Torr / Ambient temperature 3: MeNH2 / methanol / 14 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 15 p. 2765 - 2778
反应条件
lithium aluminium tetrahydride in tetrahydrofuran; dichloromethane 96 h; Heating;
参考文献
Ganellin, C. Robin; Leurquin, Fabien; Piripitsi, Antonia; Arrang, Jean-Michel; Garbarg, Monique; Ligneau, Xavier; Schunack, Walter; Schwartz, Jean-Charles
Archiv der Pharmazie, 1998 , vol. 331, # 12 p. 395 - 404
反应条件
methylamine in methanol 14 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 15 p. 2765 - 2778
反应条件
1: pyridine / tetrahydrofuran / 20 °C 2: sodium azide / dimethylformamide / 20 °C 3: 94 percent / Ph3P; H2O / tetrahydrofuran / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 14 p. 4098 - 4115
反应条件
1.1: 4-methylmorpholine; isobutylchloroformate / tetrahydrofuran / 0.5 h / -20 - -10 °C 1.2: 97 percent / NH3 / methanol; tetrahydrofuran 2.1: borane / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 14 p. 4098 - 4115
反应条件
1: sodium azide / dimethylformamide / 20 °C 2: 94 percent / Ph3P; H2O / tetrahydrofuran / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 14 p. 4098 - 4115
