反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran; ethylbenzene / 1 h / -78 °C
1.2: 12.5 h / 20 °C
2.1: triethylamine; para-formaldehyde; triphenylphosphine; palladium diacetate / methanol; N,N-dimethyl-formamide / 16 h / 20 °C / 3750.38 Torr
3.1: diisobutylaluminium hydride / dichloromethane / 1.5 h / -78 °C
View Scheme
参考文献
UCB PHARMA S.A.; BENTLEY, Jonathan Mark; BROOKINGS, Daniel Christopher; BROWN, Julien Alistair; CAIN, Thomas Paul; CHOVATIA, Praful Tulshi; FOLEY, Anne Marie; GALLIMORE, Ellen Olivia; GLEAVE, Laura Jane; HEIFETZ, Alexander; HORSLEY, Helen Tracey; HUTCHINGS, Martin Clive; JACKSON, Victoria Elizabeth; JOHNSON, James Andrew; JOHNSTONE, Craig; KROEPLIEN, Boris; LECOMTE, Fabien Claude; LEIGH, Deborah; LOWE, Martin Alexander; MADDEN, James; PORTER, John Robert; QUINCEY, Joanna Rachel; REED, Laura Claire; REUBERSON, James Thomas; RICHARDSON, Anthony John; RICHARDSON, Sarah Emily; SELBY, Matthew Duncan; SHAW, Michael Alan; ZHU, Zhaoning
Patent: WO2014/9295 A1, 2014 ;
