N-苯甲酰-L-丙氨酸甲酯合成路线 （共 47 条）
反应条件
sodium hydroxide in water T=40°C; 0.2 h; titrisol buffer pH 8, carboxylesterase NP; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Smeets, J. W. H.; Kieboom, A. P. G.
Recueil des Travaux Chimiques des Pays-Bas, 1992 , vol. 111, # 11 p. 490 - 495
反应条件
T=25°C; 6 h; phosphate buffer, protease N, pH 6.8; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Crich, Joyce Z.; Brieva, Rosario; Marquart, Peer; Gu, Rui-Lin; Flemming, Steffen; Sih, Charles J.
Journal of Organic Chemistry, 1993 , vol. 58, # 12 p. 3252 - 3258
反应条件
sulfuryl dichloride; dibenzoyl peroxide in benzene
1 h; Heatingreactions with var. reagents between var. conditions; with deuteriated analogue too; Product distribution;
参考文献
Bowman, Nigel J.; Hay, Michael P.; Love, Stephen G.; Easton, Christopher J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 259 - 264
反应条件
1: With Mesityl-Li in tetrahydrofuran; pentane
Metallation; lithiation; 1 h;
2: With 1-[5'-toluenesulfonyl-2'-(methylamino)phenyl]-1,2,3,4-tetrahydroisoquinoline in tetrahydrofuran; pentane
T=-78 - -20°C; deracemization; Title compound not separated from byproducts;
参考文献
Coghlan, Daniel R.; Easton, Christopher J.; Tiekink, Edward R. T.
Australian Journal of Chemistry, 2000 , vol. 53, # 7 p. 551 - 556
反应条件
T=25°C; 6 h; phosphate buffer, protease N, pH 6.8; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Crich, Joyce Z.; Brieva, Rosario; Marquart, Peer; Gu, Rui-Lin; Flemming, Steffen; Sih, Charles J.
Journal of Organic Chemistry, 1993 , vol. 58, # 12 p. 3252 - 3258
反应条件
benzeneselenol; sodium hydride
1.) THF, 2.) HMPA, 10 h, reflux; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Liotta, Dennis; Sunay, Ustun; Santiesteban, Hector; Markiewicz, William
Journal of Organic Chemistry, 1981 , vol. 46, # 13 p. 2605 - 2610
反应条件
1: tBuOCl / methanol
2: Et3N / CH2Cl2
3: aq. NaOH / dioxane
View Scheme
参考文献
Kolar,A.J.; Olsen,R.K.
Synthesis, 1977 , p. 457 - 459
