4-[(4-甲氧基苯甲酰基)氨基]丁酸合成路线 （共 5 条）
反应条件
thionyl chloride in dichloromethane; toluene
参考文献
Hoffmann-La Roche Inc.
Patent: US4369139 A1, 1983 ;
反应条件
hydrogenchloride; sodium hydroxide; phosphoric acid in P2O5; water; acetone; Petroleum ether; [14C]-4-Aminobutyric acid
参考文献
Hoffmann-La Roche Inc.
Patent: US4369139 A1, 1983 ;
反应条件
1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
2: N,N-dimethyl-formamide / 20 °C
View Scheme
参考文献
Donato, Loic; Mourot, Alexandre; Davenport, Christopher M.; Herbivo, Cyril; Warther, David; Leonard, Jeremie; Bolze, Frederic; Nicoud, Jean-Francois; Kramer, Richard H.; Goeldner, Maurice; Specht, Alexandre
Angewandte Chemie - International Edition, 2012 , vol. 51, # 8 p. 1840 - 1843
反应条件
in N,N-dimethyl-formamide
T=20°C;
参考文献
Donato, Loic; Mourot, Alexandre; Davenport, Christopher M.; Herbivo, Cyril; Warther, David; Leonard, Jeremie; Bolze, Frederic; Nicoud, Jean-Francois; Kramer, Richard H.; Goeldner, Maurice; Specht, Alexandre
Angewandte Chemie - International Edition, 2012 , vol. 51, # 8 p. 1840 - 1843
反应条件
Tris-HCl buffer; human liver carboxylesterase pI 5.3
T=37°C; Hydrolysis; pH=7.4; Enzyme kinetics; Further Variations:Reagents;
参考文献
Takai, Satomi; Matsuda, Ayuka; Usami, Yoshiko; Adachi, Tetsuo; Sugiyama, Tadashi; Katagiri, Yoshihiro; Tatematsu, Masae; Hirano, Kazuyuki
Biological and Pharmaceutical Bulletin, 1997 , vol. 20, # 8 p. 869 - 873
