4-甲基-2-甲硫基嘧啶-5-甲酸乙酯合成路线 （共 16 条）
反应条件
sodium acetate in DMF (N,N-dimethyl-formamide) T=80°C; 4 h;
参考文献
KUMIAI CHEMICAL INDUSTRY CO., LTD.; Ihara Chemical Industry Co., Ltd.
Patent: EP1439169 A1, 2004 ;
Location in patent: Page 95 ;
反应条件
sodium acetate in N,N-dimethyl-formamide T=80°C; 3.5 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; POONI, Parminder, Kaur; MERCHANT, Kevin, John; KERR, Catrina, Morvern; HARRISON, David
Patent: WO2011/83316 A1, 2011 ;
Location in patent: Page/Page column 53 ;
WO 2011/083316 A1
反应条件
triethylamine in ethanol 48 h; Reflux;
参考文献
MERCK PATENT GMBH; SCHIEMANN, Kai; SCHULTZ, Melanie; STAEHLE, Wolfgang; KOBER, Ingo; WIENKE, Dirk; KRIER, Mireille
Patent: WO2010/63352 A1, 2010 ;
Location in patent: Page/Page column 88-89 ;
WO 2010/063352 A1
反应条件
1: With sodium hydrogencarbonate in N,N-dimethyl-formamide T=75°C; Biginelli type reaction; 2: With 2-hydroxy-1,3-isoindolinedione; oxygen; [Co(O2CCH3)2]*4H2O in dichloromethane T=80°C; P=760.051 Torr; 1.5 h;
参考文献
Tetrahedron, , vol. 67, # 31 p. 5615 - 5620
反应条件
triethylamine in ethanol 2 h; Reflux;
参考文献
MERCK PATENT GMBH; BURGDORF, Lars; KUHN, Daniel; ROSS, Tatjana; DEUTSCH, Carl
Patent: WO2014/23385 A1, 2014 ;
Location in patent: Page/Page column 73; 74; 75 ;
反应条件
1: With sodium hydrogencarbonate in N,N-dimethyl-formamide T=75°C; Biginelli type reaction; 2: With 2-hydroxy-1,3-isoindolinedione; oxygen; [Co(O2CCH3)2]*4H2O in dichloromethane T=80°C; P=760.051 Torr; 1 h;
参考文献
Tetrahedron, , vol. 67, # 31 p. 5615 - 5620
反应条件
sodium acetate in N,N-dimethyl-formamide T=80 - 90°C; 12 h;
参考文献
Sansebastiano; Mosti; Menozzi; Schenone; Muratore; Petta; Debbia; Pesce Schito; Schito
Farmaco, 1993 , vol. 48, # 3 p. 335 - 355
反应条件
[bis(acetoxy)iodo]benzene in dichloromethane T=20°C; 1 h;
参考文献
Karade, Nandkishor N.; Gampawar V, Sumit; Tale, Nilesh P.; Kedar, Sanjay B.
Journal of Heterocyclic Chemistry, 2010 , vol. 47, # 3 p. 740 - 744
反应条件
1: acetic anhydride / 5 h / 130 °C 2: sodium acetate / N,N-dimethyl-formamide / 3.5 h / 80 °C View Scheme
参考文献
WO2011/83316 A1, ;
WO 2011/083316 A1
参考文献
Huaxue Xuebao, , vol. 23, p. 145,150
Scientia Sinica (English Edition), , vol. 6, p. 853
Chem.Abstr., , p. 14626
