2-氰基-2-甲基丙酸甲酯合成路线 （共 14 条）
反应条件
potassium carbonate in acetone
参考文献
Nippon Steel Corporation; Nippon Steel Chemical Co., Ltd.
Patent: US5866592 A1, 1999 ;
反应条件
sodium hydroxide; tetrabutylammomium bromide in dichloromethane T=10 - 40°C;
参考文献
WO2012/21446 A2, ;
Page/Page column 29 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=15 - 30°C; Product distribution / selectivity;
参考文献
WO2010/112482 A1, ;
Page/Page column 27 ;
反应条件
1: cyanoacetic acid ethyl ester With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h; 2: methyl iodide in tetrahydrofuran; N,N-dimethyl-formamide T=20°C; 71.75 h; Product distribution / selectivity;
参考文献
EP1717238 A1, ;
Page/Page column 60 ;
反应条件
sodium hydride in N,N,N',N',N'',N''-hexamethylphosphoric triamide T=20°C; Yield given;
参考文献
Chemische Berichte, , vol. 114, # 8 p. 2866 - 2883
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 6, p. 186,190
Chem.Abstr., , p. 20162
反应条件
sodium hydride 1.) THF, 12 h, r.t; 2.) THF, 12 h, r.t.; Yield given. Multistep reaction;
参考文献
Phosphorus and Sulfur and the Related Elements, , vol. 32, p. 153 - 162
反应条件
man zerlegt den Iminoaether durch kalte konz. Salzsaeure;
参考文献
American Chemical Journal, , vol. 18, p. 738
反应条件
1: With ammonia; hydrogen; nickel in 1-methyl-pyrrolidin-2-one; water T=80°C; P=3750.38 Torr; 1.5 h; 2: With ammonia; hydrogen; nickel in 1-methyl-pyrrolidin-2-one; water T=80°C; P=150015 Torr; Product distribution / selectivity;
参考文献
BASF SE
Patent: US2008/306299 A1, 2008 ;
Location in patent: Page/Page column 4 ;
反应条件
ammonia; hydrogen; mixture of 28percent NiO, 28percent CoO, 13percent CuO, 31percent ZrO2; hydrogenated in methanol T=100°C; P=150015 Torr; Product distribution / selectivity;
参考文献
BASF SE
Patent: US2008/306299 A1, 2008 ;
Location in patent: Page/Page column 4-5 ;
