5-氯-1,3-苯并二噁唑合成路线 （共 30 条）
反应条件
N-chloro-succinimide in various solvent(s) T=27°C; 1 h;
参考文献
Yadav; Reddy; Basak; Narsaiah
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 1 p. 77 - 82
反应条件
1,3-Dichloro-5,5-dimethyl-2,4-imidazolidinedione in acetic acid T=60 - 95°C; 1 h; Product distribution / selectivity;
参考文献
UBE INDUSTRIES, LTD.
Patent: WO2007/20964 A1, 2007 ;
Location in patent: Page/Page column 10-11 ;
反应条件
1: 1-chloro-3,4-methylenedioxybenzene With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 0.5 h; 2: carbon dioxide in tetrahydrofuran T=-78 - 20°C;
参考文献
Ple, Patrick A.; Green, Tim P.; Hennequin, Laurent F.; Curwen, Jon; Fennell, Michael; Allen, Jack; Lambert-Van Der Brempt, Christine; Costello, Gerard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 871 - 887
反应条件
1.1: LDA / tetrahydrofuran / 0.5 h / -78 °C 1.2: 84 percent / tetrahydrofuran / -78 - 20 °C 2.1: 81 percent / diphenoxyphosphoryl azide; Et3N / dioxane / 4 h / 100 °C 3.1: 93 percent / TFA / CH2Cl2 / 3 h / 20 °C View Scheme
参考文献
Ple, Patrick A.; Green, Tim P.; Hennequin, Laurent F.; Curwen, Jon; Fennell, Michael; Allen, Jack; Lambert-Van Der Brempt, Christine; Costello, Gerard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 871 - 887
反应条件
1.1: palladium diacetate; potassium iodide; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; triethylamine / ethyl acetate / 16 h / 50 °C / |Inert atmosphere; |Schlenk technique 2.1: methanol / ethyl acetate / 1 h / -5 - 20 °C / |Inert atmosphere; |Schlenk technique 2.2: 4 h / 20 °C / |Inert atmosphere; |Schlenk technique View Scheme
参考文献
Guerrand, Helene D. S.; Marciasini, Ludovic D.; Jousseaume, Melissa; Vaultier, Michel; Pucheault, Mathieu
Chemistry - A European Journal, 2014 , vol. 20, # 19 p. 5573 - 5579
反应条件
caesium carbonate in 2,2,2-trifluoroethanol 14 h; Irradiation;
参考文献
Protti, Stefano; Fagnoni, Maurizio; Albini, Angelo
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 15 p. 2868 - 2871
反应条件
1.1: LDA / tetrahydrofuran / 0.5 h / -78 °C 1.2: 84 percent / tetrahydrofuran / -78 - 20 °C 2.1: 81 percent / diphenoxyphosphoryl azide; Et3N / dioxane / 4 h / 100 °C View Scheme
参考文献
Ple, Patrick A.; Green, Tim P.; Hennequin, Laurent F.; Curwen, Jon; Fennell, Michael; Allen, Jack; Lambert-Van Der Brempt, Christine; Costello, Gerard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 871 - 887
反应条件
1: With ethidium Bromide; magnesium; iron(II) chloride; magnesium chloride in tetrahydrofuran T=22 - 52°C; 23 h; 2: With water in tetrahydrofuran
参考文献
Bogdanovi, Borislav; Schwickardi, Manfred
Angewandte Chemie - International Edition, 2000 , vol. 39, # 24 p. 4610 - 4612
反应条件
triethylamine in 2,2,2-trifluoroethanol 7 h; Photolysis;
参考文献
Dichiarante, Valentina; Fagnoni, Maurizio; Albini, Angelo
Angewandte Chemie - International Edition, 2007 , vol. 46, # 34 p. 6495 - 6498
反应条件
Herrmann's palladacycle; C29H45Pt; caesium carbonate in water; N,N-dimethyl-formamide T=130°C; 0.5 h; Inert atmosphereMicrowave irradiation;
参考文献
Yu, Chao-Wu; Chen, Grace S.; Huang, Chen-Wei; Chern, Ji-Wang
Organic Letters, 2012 , vol. 14, # 14 p. 3688 - 3691
