5-叔丁基-1,3-苯并二氧戊环合成路线 （共 3 条）
反应条件
1,3-dimethyl-imidazolidin-2-one; lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=185°C; 12 h; further reagent: NaN(SiMe3)2;
参考文献
Hwu, Jih Ru; Wong, Fung Fuh; Huang, Jiann-Jyh; Tsay, Shwu-Chen
Journal of Organic Chemistry, 1997 , vol. 62, # 12 p. 4097 - 4104
反应条件
1: 3,4-dihydroxy-1-tert-butylbenzene With sodium hydroxide in dimethyl sulfoxide
T=90°C; 1 h;
2: diiodomethane in dimethyl sulfoxide
T=90°C; 2 h;
参考文献
Cai, Xiong; Qian, Changgeng; Zhai, Haixiao
Patent: US2008/234314 A1, 2008 ;
Location in patent: Page/Page column 56 ;
US 20080234314 A1
反应条件
1.54H2O*Cl2Ni; ICy*HBF4 in tetrahydrofuran
T=-10°C; Kumada coupling reaction; 1.5 h; Inert atmosphere;
参考文献
Joshi-Pangu, Amruta; Wang, Chao-Yuan; Biscoe, Mark R.
Journal of the American Chemical Society, 2011 , vol. 133, # 22 p. 8478 - 8481
