2,3,4,5-四氢-1H-2-苯并氮杂卓合成路线 （共 18 条）
反应条件
1: 93 percent / potassium carbonate / H2O; toluene; benzene / 1.) 0 deg C, 30 min; 2.) 35 deg C, 24 h 2: methanesulphonic acid / acetic anhydride; 1,2-dichloro-ethane / 35 °C 3: 70 percent / methanesulphonic acid / acetic anhydride; 1,2-dichloro-ethane / 35 °C 4: sodium bis(2-methoxyethoxy)aluminium hydride / benzene / 10 h / 80 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1977 - 1982
反应条件
1: methanesulphonic acid / acetic anhydride; 1,2-dichloro-ethane / 35 °C 2: 70 percent / methanesulphonic acid / acetic anhydride; 1,2-dichloro-ethane / 35 °C 3: sodium bis(2-methoxyethoxy)aluminium hydride / benzene / 10 h / 80 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1977 - 1982
参考文献
Chemische Berichte, , vol. 56, p. 694
反应条件
1: hydrochloric acid / 130 °C 2: diluted alkaline solution View Scheme
参考文献
Chemische Berichte, , vol. 56, p. 694
反应条件
1: nickel; decalin / 115 °C / Hydrogenation 2: hydrochloric acid / 130 °C 3: diluted alkaline solution View Scheme
参考文献
Chemische Berichte, , vol. 56, p. 694
反应条件
sulfuric acid; potassium nitrate T=0 - 20°C;
参考文献
Grunewald, Gary L.; Dahanukar, Vilas H.; Criscione, Kevin R.
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 8 p. 1957 - 1965
反应条件
1: 60 percent / KNO3; conc. H2SO4 / 0 - 20 °C
2: 95 percent / H2 / PtO2 / ethanol / 3 h / 2585.74 Torr
View Scheme
参考文献
Grunewald, Gary L.; Dahanukar, Vilas H.; Criscione, Kevin R.
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 8 p. 1957 - 1965
反应条件
1: 2,3,4,5-tetrahydro-1H-benzo[c]azepine With n-butyllithium in tetrahydrofuran; hexane
T=-78 - 0°C;
2: benzyl bromide in tetrahydrofuran; hexane
T=-78 - -40°C; 1 h;
参考文献
Kessar, Satinder V.; Singh, Paramjit; Singh, Kamal Nain; Venugopalan; Kaur, Amarjit; Mahendru, Manu; Kapoor, Rajiv
Tetrahedron Letters, 2005 , vol. 46, # 39 p. 6753 - 6755
