3,4-二氢-2H-1,5-苯并二氧环庚烷合成路线 （共 21 条）
反应条件
1: zinc(II) chloride / dichloromethane / 20 °C 2: bromine / ethanol / 1 h / 20 °C 3: ethanol / 2 h / |Reflux 4: AlCl3, aluminium chloride / benzene / 10 h / |Reflux View Scheme
参考文献
Huang, Wei-Bin; Guo, Ying; Jiang, Jian-An; Pan, Xian-Dao; Liao, Dao-Hua; Ji, Ya-Fei
Synlett, 2013 , vol. 24, # 6 art. no. ST-2013-W0052-L, p. 741 - 746
反应条件
1: zinc(II) chloride / dichloromethane / 20 °C 2: bromine / ethanol / 1 h / 20 °C 3: ethanol / 2 h / |Reflux View Scheme
参考文献
Synlett, , vol. 24, # 6 art. no. ST-2013-W0052-L, p. 741 - 746
反应条件
sulfuric acid; nitric acid; acetic anhydride in methanol; acetic acid; toluene
参考文献
Hoffmann-La Roche Inc.
Patent: US4435406 A1, 1984 ;
反应条件
1: 88 percent / HNO3; AcOH / CHCl3 / 24 h / 0 - 20 °C 2: 32 percent / Fe; AcOH / 2 h / Heating View Scheme
参考文献
Ouerghui, Abid; Hlel, Faouzi; Meganem, Faouzi
Revue Roumaine de Chimie, 2003 , vol. 48, # 2 p. 125 - 130
反应条件
bromine; sodium acetate; sodium carbonate in hexane; water; acetic acid
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6235771 B1, 2001 ;
反应条件
zinc(II) chloride in dichloromethane T=20°C; Friedel-Crafts Acylation;
参考文献
Huang, Wei-Bin; Guo, Ying; Jiang, Jian-An; Pan, Xian-Dao; Liao, Dao-Hua; Ji, Ya-Fei
Synlett, 2013 , vol. 24, # 6 art. no. ST-2013-W0052-L, p. 741 - 746
反应条件
aluminium trichloride in dichloromethane T=20°C; 3 h;
参考文献
Pharmaceutical Chemistry Journal, , vol. 23, # 4 p. 322 - 324
Khimiko-Farmatsevticheskii Zhurnal, , vol. 23, # 4 p. 435 - 437
反应条件
nitric acid T=20 - 30°C; 1 h; Yield given. Yields of byproduct given;
参考文献
Takakis, Ioannis M.; Hadjimihalakis, Phaedon M.
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 3 p. 625 - 634
反应条件
aluminium trichloride in dichloromethane T=20°C; 3 h;
参考文献
Daukshas, V. K.; Gaidyalis, P. G.; Labanauskas, L. K.; Udrenaite, E. B.; Gasneravichene, G. A.; Raguotene, N. V.
Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 4 p. 322 - 324
Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 4 p. 435 - 437
反应条件
aluminium trichloride in dichloromethane T=20°C; 3 h;
参考文献
Daukshas, V. K.; Gaidyalis, P. G.; Labanauskas, L. K.; Udrenaite, E. B.; Gasneravichene, G. A.; Raguotene, N. V.
Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 4 p. 322 - 324
Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 4 p. 435 - 437
