(3R,4S)-4-氨基-3-羟基-5-苯基戊酸合成路线 （共 5 条）
反应条件
hydrogen; palladium hydroxide - carbon in methanol; water
26 h;
参考文献
Andres, Jose M; Pedrosa, Rafael; Perez, Alberto; Perez-Encabo, Alfonso
Tetrahedron, 2001 , vol. 57, # 40 p. 8521 - 8530
反应条件
1: 52 percent / tetrahydrofuran / 1.5 h / 0 °C
2: 85 percent / trifluoroacetic acid / 4 h / 20 °C
3: 97 percent / H2 / 20 percent Pd(OH)2-C / methanol; H2O / 26 h
View Scheme
参考文献
Andres, Jose M; Pedrosa, Rafael; Perez, Alberto; Perez-Encabo, Alfonso
Tetrahedron, 2001 , vol. 57, # 40 p. 8521 - 8530
反应条件
1: 85 percent / trifluoroacetic acid / 4 h / 20 °C
2: 97 percent / H2 / 20 percent Pd(OH)2-C / methanol; H2O / 26 h
View Scheme
参考文献
Andres, Jose M; Pedrosa, Rafael; Perez, Alberto; Perez-Encabo, Alfonso
Tetrahedron, 2001 , vol. 57, # 40 p. 8521 - 8530
反应条件
hydrogenchloride in 1,4-dioxane
0.5 h; Ambient temperature;
参考文献
Rich; Sun; Ulm
Journal of Medicinal Chemistry, 1980 , vol. 23, # 1 p. 27 - 33
反应条件
1: 2 N NaOH / dioxane; H2O / 0.5 h
2: 9.3 mg / HCl / dioxane / 0.5 h / Ambient temperature
View Scheme
参考文献
Rich; Sun; Ulm
Journal of Medicinal Chemistry, 1980 , vol. 23, # 1 p. 27 - 33
