(3S,4s)-4-氨基-3-羟基-5-苯基戊酸合成路线 （共 26 条）
反应条件
sodium hydroxide in 1,4-dioxane; water Yield given;
参考文献
Fuji, Kaoru; Kawabata, Takeo; Kiryu, Yoshimitsu; Sugiura, Yukio
Heterocycles, 1996 , vol. 42, # 2 p. 701 - 722
反应条件
hydrogen; palladium hydroxide - carbon in methanol; water
22 h;
参考文献
Andres, Jose M; Pedrosa, Rafael; Perez, Alberto; Perez-Encabo, Alfonso
Tetrahedron, 2001 , vol. 57, # 40 p. 8521 - 8530
反应条件
hydrogenchloride in 1,4-dioxane
0.5 h; Ambient temperature;
参考文献
Rich; Sun; Ulm
Journal of Medicinal Chemistry, 1980 , vol. 23, # 1 p. 27 - 33
反应条件
hydrogenchloride
T=80°C;
参考文献
Kondekar, Nagendra B.; Kandula, Subba Rao V.; Kumar, Pradeep
Tetrahedron Letters, 2004 , vol. 45, # 28 p. 5477 - 5479
参考文献
Kawabata; Kiryu; Sugiura; Fuji
Tetrahedron Letters, 1993 , vol. 34, # 32 p. 5127 - 5130
反应条件
1: 95 percent / LiOH / tetrahydrofuran; H2O / 24 h
2: HCOOH / 6 h / 20 °C
View Scheme
参考文献
Meloni, Marco Massimiliano; Taddei, Maurizio
Organic Letters, 2001 , vol. 3, # 3 p. 337 - 340
反应条件
1: (DHQ)2PHAL; K2[OsO2(OH)2]; LiOH / 2-methyl-propan-2-ol; H2O / 0 - 20 °C
2: 87 percent / HCl / methanol / Heating
3: Et3N / CH2Cl2 / 0 - 20 °C
4: 89 percent / p-toluenesulfonic acid / CH2Cl2 / 20 °C
5: 76 percent / DIBAL-H / CH2Cl2 / -78 - 20 °C
6: 60 percent / tetrahydrofuran / 0 - 20 °C
7: 90 percent / H2 / Pd/C / ethyl acetate; methanol
8: 67 percent / AcOH / toluene / Heating
9: 73 percent / cc. HCl / 80 °C
View Scheme
参考文献
Kondekar, Nagendra B.; Kandula, Subba Rao V.; Kumar, Pradeep
Tetrahedron Letters, 2004 , vol. 45, # 28 p. 5477 - 5479
反应条件
1: 60 percent / tetrahydrofuran / 0 - 20 °C
2: 90 percent / H2 / Pd/C / ethyl acetate; methanol
3: 67 percent / AcOH / toluene / Heating
4: 73 percent / cc. HCl / 80 °C
View Scheme
参考文献
Kondekar, Nagendra B.; Kandula, Subba Rao V.; Kumar, Pradeep
Tetrahedron Letters, 2004 , vol. 45, # 28 p. 5477 - 5479
反应条件
1: Et3N / CH2Cl2 / 0 - 20 °C
2: 89 percent / p-toluenesulfonic acid / CH2Cl2 / 20 °C
3: 76 percent / DIBAL-H / CH2Cl2 / -78 - 20 °C
4: 60 percent / tetrahydrofuran / 0 - 20 °C
5: 90 percent / H2 / Pd/C / ethyl acetate; methanol
6: 67 percent / AcOH / toluene / Heating
7: 73 percent / cc. HCl / 80 °C
View Scheme
参考文献
Kondekar, Nagendra B.; Kandula, Subba Rao V.; Kumar, Pradeep
Tetrahedron Letters, 2004 , vol. 45, # 28 p. 5477 - 5479
反应条件
1: 89 percent / p-toluenesulfonic acid / CH2Cl2 / 20 °C
2: 76 percent / DIBAL-H / CH2Cl2 / -78 - 20 °C
3: 60 percent / tetrahydrofuran / 0 - 20 °C
4: 90 percent / H2 / Pd/C / ethyl acetate; methanol
5: 67 percent / AcOH / toluene / Heating
6: 73 percent / cc. HCl / 80 °C
View Scheme
参考文献
Kondekar, Nagendra B.; Kandula, Subba Rao V.; Kumar, Pradeep
Tetrahedron Letters, 2004 , vol. 45, # 28 p. 5477 - 5479
