5-溴-4-氯-3-吲哚基-B-D-半乳糖甘(X-gal)合成路线 （共 34 条）
反应条件
1.1: 84 percent / Fmoc-Cl; NMM / tetrahydrofuran / 0.5 h / -15 °C
2.1: HCl / ethyl acetate; H2O / 0.5 h
2.2: 77 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C
3.1: 50 percent / NaOH / methanol; H2O / 3 h / pH 8 - 9
View Scheme
参考文献
Babu, V.V. Suresh; Tantry
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 12 p. 2708 - 2712
反应条件
1.1: HCl / ethyl acetate; H2O / 0.5 h
1.2: 77 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C
2.1: 50 percent / NaOH / methanol; H2O / 3 h / pH 8 - 9
View Scheme
参考文献
Babu, V.V. Suresh; Tantry
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 12 p. 2708 - 2712
参考文献
Sivanandaiah, K. M.; Babu, V. V. Suresh; Gangadhar, B. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1994 , vol. 33, # 7 p. 620 - 623
反应条件
proline-specific-endopeptidase in water
T=30°C; at pH=7.6; different reagents and other products; Product distribution;
参考文献
Hartrodt; Neubert; Fischer; Demuth; Yoshimoto; Barth
Pharmazie, 1982 , vol. 37, # 1 p. 72 - 73
