5-溴-4-氯-3-吲哚基-B-D-半乳糖甘(X-gal)合成路线 （共 34 条）
反应条件
1: 4N HCl / dioxane
2: 75 percent / TEA / dimethylformamide / 48 h
3: 4N HCl / dioxane
4: 89 percent / TEA / dimethylformamide / 48 h
5: 4N HCl / dioxane
6: 76 percent / TEA / dimethylformamide / 48 h
7: 92 percent / H2 / 10percent Pd/C / methanol / 4 h
View Scheme
参考文献
Banfi, Stefano; Rubino, Federico Maria; Sommaruga, Maurizio; Restani, Patrizia
Gazzetta Chimica Italiana, 1988 , vol. 118, # 1 p. 41 - 46
反应条件
1: 75 percent / TEA / dimethylformamide / 48 h
2: 4N HCl / dioxane
3: 89 percent / TEA / dimethylformamide / 48 h
4: 4N HCl / dioxane
5: 76 percent / TEA / dimethylformamide / 48 h
6: 92 percent / H2 / 10percent Pd/C / methanol / 4 h
View Scheme
参考文献
Banfi, Stefano; Rubino, Federico Maria; Sommaruga, Maurizio; Restani, Patrizia
Gazzetta Chimica Italiana, 1988 , vol. 118, # 1 p. 41 - 46
反应条件
1: 89 percent / TEA / dimethylformamide / 48 h
2: 4N HCl / dioxane
3: 76 percent / TEA / dimethylformamide / 48 h
4: 92 percent / H2 / 10percent Pd/C / methanol / 4 h
View Scheme
参考文献
Banfi, Stefano; Rubino, Federico Maria; Sommaruga, Maurizio; Restani, Patrizia
Gazzetta Chimica Italiana, 1988 , vol. 118, # 1 p. 41 - 46
反应条件
1: 4N HCl / dioxane
2: 89 percent / TEA / dimethylformamide / 48 h
3: 4N HCl / dioxane
4: 76 percent / TEA / dimethylformamide / 48 h
5: 92 percent / H2 / 10percent Pd/C / methanol / 4 h
View Scheme
参考文献
Banfi, Stefano; Rubino, Federico Maria; Sommaruga, Maurizio; Restani, Patrizia
Gazzetta Chimica Italiana, 1988 , vol. 118, # 1 p. 41 - 46
反应条件
1: 4N HCl / dioxane
2: 76 percent / TEA / dimethylformamide / 48 h
3: 92 percent / H2 / 10percent Pd/C / methanol / 4 h
View Scheme
参考文献
Banfi, Stefano; Rubino, Federico Maria; Sommaruga, Maurizio; Restani, Patrizia
Gazzetta Chimica Italiana, 1988 , vol. 118, # 1 p. 41 - 46
反应条件
1.1: 87 percent / Fmoc-Cl; NMM / tetrahydrofuran / 0.5 h / -15 °C
2.1: HCl / ethyl acetate; H2O / 0.5 h
2.2: 81 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C
3.1: 80 percent / Fmoc-Cl; NMM / tetrahydrofuran / 0.5 h / -15 °C
4.1: HCl / ethyl acetate; H2O / 0.5 h
4.2: 80 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C
5.1: 84 percent / Fmoc-Cl; NMM / tetrahydrofuran / 0.5 h / -15 °C
6.1: HCl / ethyl acetate; H2O / 0.5 h
6.2: 77 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C
7.1: 50 percent / NaOH / methanol; H2O / 3 h / pH 8 - 9
View Scheme
参考文献
Babu, V.V. Suresh; Tantry
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 12 p. 2708 - 2712
反应条件
1.1: HCl / ethyl acetate; H2O / 0.5 h
1.2: 86 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C
2.1: 87 percent / Fmoc-Cl; NMM / tetrahydrofuran / 0.5 h / -15 °C
3.1: HCl / ethyl acetate; H2O / 0.5 h
3.2: 81 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C
4.1: 80 percent / Fmoc-Cl; NMM / tetrahydrofuran / 0.5 h / -15 °C
5.1: HCl / ethyl acetate; H2O / 0.5 h
5.2: 80 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C
6.1: 84 percent / Fmoc-Cl; NMM / tetrahydrofuran / 0.5 h / -15 °C
7.1: HCl / ethyl acetate; H2O / 0.5 h
7.2: 77 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C
8.1: 50 percent / NaOH / methanol; H2O / 3 h / pH 8 - 9
View Scheme
参考文献
Babu, V.V. Suresh; Tantry
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 12 p. 2708 - 2712
反应条件
1.1: HCl / ethyl acetate; H2O / 0.5 h
1.2: 81 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C
2.1: 80 percent / Fmoc-Cl; NMM / tetrahydrofuran / 0.5 h / -15 °C
3.1: HCl / ethyl acetate; H2O / 0.5 h
3.2: 80 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C
4.1: 84 percent / Fmoc-Cl; NMM / tetrahydrofuran / 0.5 h / -15 °C
5.1: HCl / ethyl acetate; H2O / 0.5 h
5.2: 77 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C
6.1: 50 percent / NaOH / methanol; H2O / 3 h / pH 8 - 9
View Scheme
参考文献
Babu, V.V. Suresh; Tantry
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 12 p. 2708 - 2712
反应条件
1.1: HCl / ethyl acetate; H2O / 0.5 h
1.2: 80 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C
2.1: 84 percent / Fmoc-Cl; NMM / tetrahydrofuran / 0.5 h / -15 °C
3.1: HCl / ethyl acetate; H2O / 0.5 h
3.2: 77 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C
4.1: 50 percent / NaOH / methanol; H2O / 3 h / pH 8 - 9
View Scheme
参考文献
Babu, V.V. Suresh; Tantry
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 12 p. 2708 - 2712
反应条件
1.1: 80 percent / Fmoc-Cl; NMM / tetrahydrofuran / 0.5 h / -15 °C
2.1: HCl / ethyl acetate; H2O / 0.5 h
2.2: 80 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C
3.1: 84 percent / Fmoc-Cl; NMM / tetrahydrofuran / 0.5 h / -15 °C
4.1: HCl / ethyl acetate; H2O / 0.5 h
4.2: 77 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C
5.1: 50 percent / NaOH / methanol; H2O / 3 h / pH 8 - 9
View Scheme
参考文献
Babu, V.V. Suresh; Tantry
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 12 p. 2708 - 2712
