5-溴-4-氯-3-吲哚基-B-D-半乳糖甘(X-gal)合成路线 （共 34 条）
反应条件
proline-specific-endopeptidase in water T=30°C; at pH=7.6; different reagents and other products; Product distribution;
参考文献
Hartrodt; Neubert; Fischer; Demuth; Yoshimoto; Barth
Pharmazie, 1982 , vol. 37, # 1 p. 72 - 73
反应条件
1: With formic acid; palladium on activated charcoal in methanol
T=20°C; 3 h;
2: With sodium hydrogencarbonate
0.333333 h;
参考文献
Tantry, Subramanyam J.; Mathad, Raveendra I.; Suresh Babu, Vommina V.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003 , vol. 42, # 9 p. 2104 - 2108
反应条件
hydrogen; palladium on activated charcoal in methanol
4 h;
参考文献
Banfi, Stefano; Rubino, Federico Maria; Sommaruga, Maurizio; Restani, Patrizia
Gazzetta Chimica Italiana, 1988 , vol. 118, # 1 p. 41 - 46
反应条件
diethylamine in dichloromethane
T=20°C; 1 h; Inert atmosphere;
参考文献
Sureshbabu, Vommina V.; Chennakrishnareddy, Gundala
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009 , vol. 48, # 7 p. 981 - 988
反应条件
1.1: 72 percent / TEA; TBDMS-OBt / tetrahydrofuran / 20 °C
2.1: 86 percent / 4-aminomethylpiperidine / CH2Cl2 / 0.5 h
3.1: 70 percent / TBDMS-OBt / tetrahydrofuran / 0.5 h / 20 °C
4.1: 81 percent / 4-aminomethylpiperidine / CH2Cl2 / 0.5 h
5.1: 79 percent / TBDMS-OBt / tetrahydrofuran / 0.5 h / 20 °C
6.1: 85 percent / 4-aminomethylpiperidine / CH2Cl2 / 0.5 h
7.1: 72 percent / TBDMS-OBt / tetrahydrofuran / 0.5 h / 20 °C
8.1: aq. HCOOH / Pd/C / methanol / 3 h / 20 °C
8.2: 80 percent / aq. NaHCO3 / 0.33 h
View Scheme
参考文献
Tantry, Subramanyam J.; Mathad, Raveendra I.; Suresh Babu, Vommina V.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003 , vol. 42, # 9 p. 2104 - 2108
反应条件
1.1: 70 percent / TBDMS-OBt / tetrahydrofuran / 0.5 h / 20 °C
2.1: 81 percent / 4-aminomethylpiperidine / CH2Cl2 / 0.5 h
3.1: 79 percent / TBDMS-OBt / tetrahydrofuran / 0.5 h / 20 °C
4.1: 85 percent / 4-aminomethylpiperidine / CH2Cl2 / 0.5 h
5.1: 72 percent / TBDMS-OBt / tetrahydrofuran / 0.5 h / 20 °C
6.1: aq. HCOOH / Pd/C / methanol / 3 h / 20 °C
6.2: 80 percent / aq. NaHCO3 / 0.33 h
View Scheme
参考文献
Tantry, Subramanyam J.; Mathad, Raveendra I.; Suresh Babu, Vommina V.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003 , vol. 42, # 9 p. 2104 - 2108
反应条件
1.1: 86 percent / 4-aminomethylpiperidine / CH2Cl2 / 0.5 h
2.1: 70 percent / TBDMS-OBt / tetrahydrofuran / 0.5 h / 20 °C
3.1: 81 percent / 4-aminomethylpiperidine / CH2Cl2 / 0.5 h
4.1: 79 percent / TBDMS-OBt / tetrahydrofuran / 0.5 h / 20 °C
5.1: 85 percent / 4-aminomethylpiperidine / CH2Cl2 / 0.5 h
6.1: 72 percent / TBDMS-OBt / tetrahydrofuran / 0.5 h / 20 °C
7.1: aq. HCOOH / Pd/C / methanol / 3 h / 20 °C
7.2: 80 percent / aq. NaHCO3 / 0.33 h
View Scheme
参考文献
Tantry, Subramanyam J.; Mathad, Raveendra I.; Suresh Babu, Vommina V.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003 , vol. 42, # 9 p. 2104 - 2108
反应条件
sodium hydroxide in methanol
pH=8 - 9; 3 h;
参考文献
Babu, V.V. Suresh; Tantry
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 12 p. 2708 - 2712
反应条件
1.1: 79 percent / TBDMS-OBt / tetrahydrofuran / 0.5 h / 20 °C
2.1: 85 percent / 4-aminomethylpiperidine / CH2Cl2 / 0.5 h
3.1: 72 percent / TBDMS-OBt / tetrahydrofuran / 0.5 h / 20 °C
4.1: aq. HCOOH / Pd/C / methanol / 3 h / 20 °C
4.2: 80 percent / aq. NaHCO3 / 0.33 h
View Scheme
参考文献
Tantry, Subramanyam J.; Mathad, Raveendra I.; Suresh Babu, Vommina V.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003 , vol. 42, # 9 p. 2104 - 2108
反应条件
1.1: 72 percent / TBDMS-OBt / tetrahydrofuran / 0.5 h / 20 °C
2.1: aq. HCOOH / Pd/C / methanol / 3 h / 20 °C
2.2: 80 percent / aq. NaHCO3 / 0.33 h
View Scheme
参考文献
Tantry, Subramanyam J.; Mathad, Raveendra I.; Suresh Babu, Vommina V.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003 , vol. 42, # 9 p. 2104 - 2108
