4-氟-4-甲基-1,1-联苯合成路线 （共 47 条）
反应条件
1: sodium sulfate / tetrahydrofuran / 24 h / 20 °C / |Schlenk technique; |Inert atmosphere
2: bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide / neat (no solvent) / 24 h / 110 °C / |Schlenk technique; |Inert atmosphere
View Scheme
参考文献
Asachenko, Andrey F.; Sorochkina, Kristina R.; Dzhevakov, Pavel B.; Topchiy, Maxim A.; Nechaev, Mikhail S.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 18 p. 3553 - 3557
反应条件
1: sodium sulfate / tetrahydrofuran / 24 h / 20 °C / |Schlenk technique; |Inert atmosphere
2: palladium diacetate; dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; potassium phosphate / neat (no solvent) / 24 h / 60 °C / |Schlenk technique; |Inert atmosphere
View Scheme
参考文献
Asachenko, Andrey F.; Sorochkina, Kristina R.; Dzhevakov, Pavel B.; Topchiy, Maxim A.; Nechaev, Mikhail S.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 18 p. 3553 - 3557
反应条件
1: dichloromethane / 4 h / 20 °C / Inert atmosphere
2: Ni(PCy3)2Cl2 / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 8 h / 90 °C / Inert atmosphere
View Scheme
参考文献
Xie, Lan-Gui; Wang, Zhong-Xia
Angewandte Chemie - International Edition, 2011 , vol. 50, # 21 p. 4901 - 4904
反应条件
potassium carbonate in water
Suzuki coupling; 94 h; Reflux;
参考文献
Iranpoor, Nasser; Firouzabadi, Habib; Safavi, Afsaneh; Motevalli, Somayeh; Doroodmand, Mohammad M.
Applied Organometallic Chemistry, 2012 , vol. 26, # 8 p. 417 - 424
反应条件
[1,3-bis(diphenylphosphino) propane] dichloronickel(II) in tetrahydrofuran
48 h; Heating; Product distribution; Further Variations:Catalysts;
参考文献
Saeki, Tomoyuki; Takashima, Yohei; Tamao, Kohei
Synlett, 2005 , # 11 art. no. Y00605ST, p. 1771 - 1774
反应条件
(i) Mg, (ii) /BRN= 506746/, (iii) HCO2H, (iv) sulfur; Multistep reaction;
参考文献
Bell,H.C. et al.
Australian Journal of Chemistry, 1979 , vol. 32, p. 1531 - 1550
反应条件
T=30°C; 20 h; Irradiation; Product distribution;
参考文献
Kelm, J.; Strauss, K.
Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy, 1981 , vol. 37, # 8 p. 689 - 692
