4-氨基-1-甲基-1H-吡咯-2-羧酸甲酯合成路线 （共 20 条）
反应条件
1: 84 percent / CH2Cl2 / 12 h / Heating 2: 93 percent / aq. NaOH / methanol / 18 h / Heating View Scheme
参考文献
Bailly; Pommery; Houssin; Henichart
Journal of Pharmaceutical Sciences, 1989 , vol. 78, # 11 p. 910 - 917
参考文献
Yamamoto, Masahiko; Zhu, Changjin; Yi, Lui; Rong, Zheng; Miura, Yoshie; Izumi, Minoru; Nakajima, Shuhei; Tanamoto, Ken-Ichi; Shimizu, Sakayu; Baba, Naomichi
Bioscience, Biotechnology and Biochemistry, 2007 , vol. 71, # 4 p. 1078 - 1082
反应条件
in dichloromethane 12 h; Heating;
参考文献
Journal of Pharmaceutical Sciences, , vol. 78, # 11 p. 910 - 917
反应条件
1: 0.15 g / 3-(diethoxy-phosphoryloxy)-1,2,3-benzotriazin-4(3H)-one; triethylamine / CH2Cl2 / 17 h 2: LiOH / tetrahydrofuran; methanol / 5 h / 60 °C View Scheme
参考文献
Bailly; Pommery; Houssin; Henichart
Journal of Pharmaceutical Sciences, 1989 , vol. 78, # 11 p. 910 - 917
反应条件
4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=20°C;
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 16 p. 6339 - 6351
反应条件
1: 84 percent / CH2Cl2 / 12 h / Heating 2: 93 percent / aq. NaOH / methanol / 18 h / Heating 3: dicyclohexylcarbodiimide, dimethylaminopyridine / CH2Cl2 / 4 h View Scheme
参考文献
Journal of Pharmaceutical Sciences, , vol. 78, # 11 p. 910 - 917
反应条件
hydrogen; palladium on activated charcoal in methanol
3 h; Ambient temperature;
参考文献
Vooturi, Sunil K.; Firestine, Steven M.
Journal of Combinatorial Chemistry, 2010 , vol. 12, # 1 p. 151 - 160
反应条件
1: 100 percent / 80 °C
2: H2 / Pd/C / methanol / 2 h / 2585.81 Torr
View Scheme
参考文献
Kumar, Rohtash; Lown, J William
Organic and biomolecular chemistry, 2003 , vol. 1, # 15 p. 2630 - 2647
反应条件
1: 1.2 kg / diethyl ether / 3 h
2: HNO3, Ac2O / -40 - 20 °C
3: 47 percent / NaOMe / 2 h / Ambient temperature
4: H2 / 10percent Pd/C / ethyl acetate / 48 h / 836 Torr
View Scheme
参考文献
Baird, Eldon E.; Dervan, Peter B.
Journal of the American Chemical Society, 1996 , vol. 118, # 26 p. 6141 - 6146
反应条件
1: HNO3, Ac2O / -40 - 20 °C
2: 47 percent / NaOMe / 2 h / Ambient temperature
3: H2 / 10percent Pd/C / ethyl acetate / 48 h / 836 Torr
View Scheme
参考文献
Baird, Eldon E.; Dervan, Peter B.
Journal of the American Chemical Society, 1996 , vol. 118, # 26 p. 6141 - 6146
