(2-氨基-5-甲基-1,3-噻唑-4-基)乙酸甲酯合成路线 （共 9 条）
反应条件
in ethanol 2 h; Heating / reflux;
参考文献
KALYPSYS, INC.
Patent: US2008/139558 A1, 2008 ;
Location in patent: Page/Page column 51 ;
US 20080139558 A1
反应条件
in water 0.25 h; Heating / reflux;
参考文献
WO2008/57336 A2, ;
Page/Page column 38 ;
反应条件
in water 1.) reflux, 15 min, 2.) RT, 12 h;
参考文献
Plouvier, Bertrand; Bailly, Christian; Houssin, Raymond; Henichart, Jean-Pierre
Heterocycles, 1991 , vol. 32, # 4 p. 693 - 701
反应条件
1: 70 percent / N-bromosuccinimide (NBS) / CCl4 / 5 h / Heating 2: 57 percent / H2O / 1.) reflux, 15 min, 2.) RT, 12 h View Scheme
参考文献
Heterocycles, , vol. 32, # 4 p. 693 - 701
反应条件
methanol; sodium 1.) Et2O, 0 deg C, 1 h, 2.) MeOH, reflux, 4 h; Multistep reaction;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 159 - 164
反应条件
isopentylnitrile in tetrahydrofuran Reflux;
参考文献
Gavardinas, Konstantinos; Green, Jonathan Edward; Jadhav, Prabhakar Kondaji; Matthews, Donald Paul
Patent: US2010/69404 A1, 2010 ;
Location in patent: Page/Page column 16 ;
反应条件
lithium hydroxide; water T=50°C; 5 h;
参考文献
KALYPSYS, INC.
Patent: US2008/139558 A1, 2008 ;
Location in patent: Page/Page column 51 ;
US 20080139558 A1
反应条件
sulfuric acid; copper(II) sulfate; sodium bromide; sodium nitrite in water
参考文献
MERCK and CO., INC.
Patent: WO2008/57336 A2, 2008 ;
Location in patent: Page/Page column 38 ;
参考文献
Yamamoto, Yohsuke; Tsuchiya, Tohru; Ochiumi, Masahide; Arai, Shin-ichi; Inamoto, Naoki; Akiba, Kin-ya
Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 1 p. 211 - 218
