4'-甲基-2,2':6',2''-三联吡啶合成路线 （共 14 条）
反应条件
1: LDA 2: NaIO4 View Scheme
参考文献
Pickaert, Guillaume; Ziessel, Raymond
Tetrahedron Letters, 1998 , vol. 39, # 21 p. 3497 - 3500
反应条件
NiCl2((PPh3)P)2 in diethyl ether
1.) rt, 15 min 2.) reflux, 48 h;
参考文献
Potts, Kevin T.; Usifer, Douglas A.; Guadalupe, Ana; Abruna, Hector D.
Journal of the American Chemical Society, 1987 , vol. 109, # 13 p. 3961 - 3967
反应条件
lithium chloride; bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide
T=130°C;
参考文献
Odobel, Fabrice; Sauvage, Jean-Pierre; Harriman, Anthony
Tetrahedron Letters, 1993 , vol. 34, # 50 p. 8113 - 8116
反应条件
ammonium acetate in acetic acid
2 h; Heating;
参考文献
Armspach, Dominique; Constable, Edwin C.; Diederich, Francois; Housecroft, Catherine E.; Nierengarten, Jean-Francois
Chemistry - A European Journal, 1998 , vol. 4, # 4 p. 723 - 733
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene
T=110°C; Substitution; Stille reaction; 16 h;
参考文献
Fallahpour
Synthesis, 2000 , # 12 p. 1665 - 1667
反应条件
1: potassium tert-butoxide / tetrahydrofuran / 14 h / Ambient temperature
2: ammonium acetate / acetic acid; tetrahydrofuran / 4 h / Heating
3: 80 percent / 1.) bis(triphenylphosphino)nickel(II) dichloride / diethyl ether / 1.) rt, 15 min 2.) reflux, 48 h
View Scheme
参考文献
Potts, Kevin T.; Usifer, Douglas A.; Guadalupe, Ana; Abruna, Hector D.
Journal of the American Chemical Society, 1987 , vol. 109, # 13 p. 3961 - 3967
反应条件
1: potassium tert-butoxide / tetrahydrofuran / 14 h / Ambient temperature
2: ammonium acetate / acetic acid; tetrahydrofuran / 4 h / Heating
3: 80 percent / 1.) bis(triphenylphosphino)nickel(II) dichloride / diethyl ether / 1.) rt, 15 min 2.) reflux, 48 h
View Scheme
参考文献
Potts, Kevin T.; Usifer, Douglas A.; Guadalupe, Ana; Abruna, Hector D.
Journal of the American Chemical Society, 1987 , vol. 109, # 13 p. 3961 - 3967
反应条件
1: ammonium acetate / acetic acid; tetrahydrofuran / 4 h / Heating
2: 80 percent / 1.) bis(triphenylphosphino)nickel(II) dichloride / diethyl ether / 1.) rt, 15 min 2.) reflux, 48 h
View Scheme
参考文献
Potts, Kevin T.; Usifer, Douglas A.; Guadalupe, Ana; Abruna, Hector D.
Journal of the American Chemical Society, 1987 , vol. 109, # 13 p. 3961 - 3967
反应条件
1: 35 percent / PBr3 / 6 h / 175 °C
2: 65 percent / (Ph3P)4Pd / toluene / 16 h / 110 °C
View Scheme
参考文献
Fallahpour
Synthesis, 2000 , # 12 p. 1665 - 1667
反应条件
in tetrahydrofuran
T=-78°C;
参考文献
Bates, Robert B.; Gordon, Bernard; Keller, Philip C.; Rund, John V.; Mills, Nancy S.,
Journal of Organic Chemistry, 1980 , vol. 45, # 1 p. 168 - 169
