4,4,4-三氟-1-(4-甲苯基)-1,3-丁二酮合成路线 （共 20 条）
反应条件
sodium hydride in tetrahydrofuran T=-5 - 20°C; Claisen condensation; 5.5 h;
参考文献
Ahlstroem, Marie M.; Ridderstroem, Marianne; Zamora, Ismael; Luthman, Kristina
Journal of Medicinal Chemistry, 2007 , vol. 50, # 18 p. 4444 - 4452
反应条件
1: para-methylacetophenone With sodium hydride in tetrahydrofuran; mineral oil T=0°C; 0.5 h; Inert atmosphere; 2: trifluoroacetic acid in tetrahydrofuran; mineral oil T=20°C; 5 h; Inert atmosphere;
参考文献
Lill, Andreas; Scholich, Klaus; Stark, Holger
Tetrahedron Letters, 2013 , vol. 54, # 49 p. 6682 - 6686
反应条件
hydrogenchloride; lithium hexamethyldisilazane in acetonitrile
参考文献
Merck Frosst Canada and Co.
Patent: US6150534 A1, 2000 ;
反应条件
sodium methylate in toluene T=20 - 110°C; 26 h; Product distribution / selectivity;
参考文献
US2008/234491 A1, ;
Page/Page column 3-4 ;
反应条件
sodium methylate in toluene T=35 - 75°C; 4 h; Product distribution / selectivity;
参考文献
US2008/234491 A1, ;
Page/Page column 4 ;
反应条件
potassium fluoride in isopropyl alcohol 10 h; Heating;
参考文献
Pashkevich; Sevenard; Khomutov; Vorontsov
Russian Chemical Bulletin, 2001 , vol. 50, # 4 p. 669 - 672
反应条件
2,2'-bi-1H-imidazole; copper (II) acetate monohydrate; potassium carbonate in dimethyl sulfoxide T=45°C; 2 h;
参考文献
Zhou, Chunmei; Zeng, Runsheng; Zou, Jianping
Chinese Journal of Chemistry, 2010 , vol. 28, # 2 p. 294 - 298
反应条件
1: 4-sulfonamide-phenyl boronic acid With di-tert-butylazodicarboxylate; copper (II) acetate monohydrate in methanol T=65°C; 1 h; 2: 1,1,1-trifluoro-4-(4`-methylphenyl)-2,4-butanedione With hydrogenchloride in 1,4-dioxane; methanol T=20 - 80°C;
参考文献
Beveridge, Ramsay E.; Fernando, Dilinie; Gerstenberger, Brian S.
Tetrahedron Letters, 2010 , vol. 51, # 38 p. 5005 - 5008
反应条件
in water; ethyl acetate 2 h; RefluxLarge scale reaction; regioselective reaction;
参考文献
Reddy, Anumula Raghupathi; Sampath, Alla; Goverdhan, Gilla; Yakambaram, Bojja; Mukkanti, Kagga; Reddy, Padi Pratap
Organic Process Research and Development, 2009 , vol. 13, # 1 p. 98 - 101
