N-Fmoc-L-谷氨酸-5-叔丁酯水合物合成路线 （共 21 条）
反应条件
4-methyl-morpholine; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=25°C;
参考文献
Sedighi, Minoo; Lipton, Mark A.
Organic Letters, 2005 , vol. 7, # 8 p. 1473 - 1475
反应条件
1: L-Glu-γ--tert-butyl ester With N,N-dicyclohexylamine in acetone T=20°C; 2: 1-[[(9H-fluoren-9-ylmethoxy)carbonyl]oxy]-2,5-pyrrolidinedione With sodium carbonate in water; acetonitrile T=0 - 20°C; pH=8; 3: With potassium hydrogensulfate in water; acetonitrile pH=2 - 3;
参考文献
Nowshuddin, Shaik; Rao; Reddy, A. Ram
Synthetic Communications, 2009 , vol. 39, # 11 p. 2022 - 2031
反应条件
sodium hydrogencarbonate in water; acetone Ambient temperature;
参考文献
Schoen, Istvan; Kisfaludy, Lajos
Synthesis, 1986 , # 4 p. 303 - 305
反应条件
triethylamine in water; acetonitrile 1 h;
参考文献
Echner, Hartmut; Voelter, Wolfgang
Liebigs Annalen der Chemie, 1988 , p. 1095 - 1098
反应条件
sodium carbonate; toluene-4-sulfonic acid 1) dioxane, gas pressure: 350 mbar, 3 d, r.t., 2) dioxane, 0 deg C to r.t., 14 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Synthesis, , # 7 p. 571 - 572
反应条件
1: diethyl ether 2: TFA / CH2Cl2 View Scheme
参考文献
Walker, Brian; Brown, Martin F.; Lynas, John F.; Martin; McDowell, Andrew; Badet, Bernard; Hill, Alan J.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2795 - 2798
反应条件
1: With sodium azide in N,N-dimethyl-formamide T=50°C; 4 h; 2: With piperidine in N,N-dimethyl-formamide
参考文献
Chen, Chun-Chi; Rajagopal, Basker; Liu, Xuan Yu; Chen, Kuan Lin; Tyan, Yu-Chang; Lin, Fui; Lin, Po-Chiao
Amino Acids, 2014 , vol. 46, # 2 p. 367 - 374
反应条件
dicyclohexyl-carbodiimide in ethyl acetate 0 deg C, 1 h; r.t., 1 h;
参考文献
Kisfaludy, Lajos; Schoen, Istvan
Synthesis, 1983 , # 4 p. 325 - 327
反应条件
benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=20°C; Esterification;
参考文献
Pudhom, Khanitha; Vilaivan, Tirayut
Tetrahedron Letters, 1999 , vol. 40, # 32 p. 5939 - 5942
反应条件
piperidine in N,N-dimethyl-formamide 0.5 h;
参考文献
UNIVERSITY OF KANSAS; THE PENN STATE RESEARCH FOUNDATION; PETERSON, Blake R.
Patent: WO2011/19942 A2, 2011 ;
Location in patent: Page/Page column 31-32 ;
