Fmoc-L-天门冬氨酸4-叔丁酯合成路线 (共 32 条)
参考文献
Boturyn, Didier; Dumy, Pascal
Tetrahedron Letters, 2001 , vol. 42, # 15 p. 2787 - 2790
反应条件
1: N-Fmoc-D-Tyr(t-Bu)-OH With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine
TentaGel RRAM solid phase resin;
2: With piperidine in N,N-dimethyl-formamide
T=50°C; 1 h;
3: N-(9-fluorenylmethoxycarbonyl)glycine; N-Fmoc-L-leucine; N-(9H-fluoren-9-ylmethyloxycarbonylamino)-L-alanine; Fmoc–Pro–OH; Fmoc-L-phenylalanine; N-(9-fluorenylmethoxycarbonyl)-L-aspartic acid-β-(tert-butyl)ester; Fmoc-O-trityl-l-threonine; fmoc-Asn(trt)-OH; fmoc-Gln(Trt)-OH; Nα-Fmoc-N(im)-trityl-L-histidine; Fmoc-Asp(OMpe)-OH; N-(9-fluorenyl)methoxycarbonyl-Trp(Boc)-OH; fmoc-L-Arg(Pbf)-OH Further stages;
参考文献
Michels, Tillmann; Doelling, Rudolf; Haberkorn, Uwe; Mier, Walter
Organic Letters, 2012 , vol. 14, # 20 p. 5218 - 5221