Fmoc-L-天门冬氨酸4-叔丁酯合成路线 （共 32 条）
参考文献
Jubilut, Guita Nicolaewsky; Cilli, Eduardo Maffud; Crusca Jr., Edson; Silva, Elias Horacio; Okada, Yoshio; Nakaie, Clovis Ryuichi
Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 3 p. 468 - 470
反应条件
1: With sodium azide in N,N-dimethyl-formamide T=50°C; 4 h; 2: With piperidine in N,N-dimethyl-formamide
参考文献
Chen, Chun-Chi; Rajagopal, Basker; Liu, Xuan Yu; Chen, Kuan Lin; Tyan, Yu-Chang; Lin, Fui; Lin, Po-Chiao
Amino Acids, 2014 , vol. 46, # 2 p. 367 - 374
反应条件
1: With sodium azide in N,N-dimethyl-formamide T=50°C; 4 h; 2: With piperidine in N,N-dimethyl-formamide
参考文献
Chen, Chun-Chi; Rajagopal, Basker; Liu, Xuan Yu; Chen, Kuan Lin; Tyan, Yu-Chang; Lin, Fui; Lin, Po-Chiao
Amino Acids, 2014 , vol. 46, # 2 p. 367 - 374
参考文献
Chemical and pharmaceutical bulletin, , vol. 50, # 9 p. 1229 - 1232
反应条件
dicyclohexyl-carbodiimide in ethyl acetate T=0 - 20°C; 1 h;
参考文献
Ziegler, Thomas; Roeseling, Dirk; Subramanian, Lakshminarayanapuram R.
Tetrahedron Asymmetry, 2002 , vol. 13, # 9 p. 911 - 914
反应条件
pyridine in N,N-dimethyl-formamide 0.75 h; Ambient temperature;
参考文献
Green, Michael; Berman, Judd
Tetrahedron Letters, 1990 , vol. 31, # 41 p. 5851 - 5852
反应条件
1: 93 percent / NaHCO3 / dimethylformamide / 24 h / Ambient temperature 2: 70.4 percent / anisole, trifluoroacetic acid / 1 h / Ambient temperature View Scheme
参考文献
Dattoli, Samantha D.; De Marco, Rossella; Baiula, Monica; Spampinato, Santi; Greco, Arianna; Tolomelli, Alessandra; Gentilucci, Luca
European Journal of Medicinal Chemistry, 2014 , vol. 73, p. 225 - 232
反应条件
1: N-α-Fmoc-L-glutamic acid γ-t-butyl ester With methanol; N-ethyl-N,N-diisopropylamine in chloroform T=20°C; 2 h; 2: With 4-methyltetrahydropyridine in chloroform; N,N-dimethyl-formamide 3: BOC-glycine; N-(9H-fluoren-9-ylmethyloxycarbonylamino)-L-alanine; fmoc-L-Ser(TBu)-OH; N-(9-fluorenylmethoxycarbonyl)-L-aspartic acid-β-(tert-butyl)ester; N-(tert-butoxycarbonyl)-L-tryptophan Further stages;
参考文献
Mikhaleva; Ivanov; Onoprienko; Prudchenko; Chikin; Yakubovskaya; Nemtsova; Bezborodova
Russian Journal of Bioorganic Chemistry, 2014 , vol. 40, # 1 p. 1 - 8
Bioorg. Khim., 2014 , vol. 40, # 1 p. 3 - 11,9
反应条件
1: fmoc-O-tert-butyl-L-tyrosine With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide in N,N-dimethyl-formamide 0.25 h; 2: in N,N-dimethyl-formamide 3: Fmoc-Arg (Boc)2-OH; N-(fluoren-9-ylmethoxycarbonyl)-L-Val; N-(9-fluorenylmethoxycarbonyl)-L-aspartic acid-β-(tert-butyl)ester; N-(fluoren-9-ylmethoxycarbonyl)-L-Lys(Nε-Boc) Further stages;
参考文献
Chemical Communications, , vol. 46, # 16 p. 2808 - 2810
反应条件
1: fmoc-O-tert-butyl-L-tyrosine With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide in N,N-dimethyl-formamide 1 h; solid phase reaction; 2: With piperidine in N,N-dimethyl-formamide 0.5 h; solid phase reaction; 3: N-(fluoren-9-ylmethoxycarbonyl)-L-Val; N-(9-fluorenylmethoxycarbonyl)-L-aspartic acid-β-(tert-butyl)ester; N-(fluoren-9-ylmethoxycarbonyl)-L-Lys(Nε-Boc); N-α-Fmoc-N-ω,N-ω'-bis-tert-butoxycarbonyl-L-arginine Further stages;
参考文献
Organic Process Research and Development, , vol. 14, # 6 p. 1313 - 1325
