1-甲基哌啶-4-甲酸盐酸盐合成路线 （共 9 条）
反应条件
formic acid 16 h; Heating;
参考文献
Gray, Allan P.; Platz, Robert D.; Henderson, Theresa R.; Chang, Timothy C. P.; Takahashi, Kazuyuki; Dretchen, Kenneth L.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 4 p. 807 - 814
反应条件
hydrogenchloride; water T=100°C; 6 h;
参考文献
F2G LIMITED
Patent: US2011/9390 A1, 2011 ;
Location in patent: Page/Page column 14 ;
反应条件
hydrogenchloride; formaldehyd in formic acid
反应条件
1: 87 percent / thionyl chloride / 3 h / -10 - 40 °C 2: DIBAL-H / hexane / 2.5 h / -70 °C View Scheme
参考文献
Gray, Allan P.; Platz, Robert D.; Henderson, Theresa R.; Chang, Timothy C. P.; Takahashi, Kazuyuki; Dretchen, Kenneth L.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 4 p. 807 - 814
反应条件
thionyl chloride in methanol
参考文献
Dynamac Corporaton
Patent: US4757079 A1, 1988 ;
反应条件
thionyl chloride T=-10 - 40°C; 3 h;
参考文献
Gray, Allan P.; Platz, Robert D.; Henderson, Theresa R.; Chang, Timothy C. P.; Takahashi, Kazuyuki; Dretchen, Kenneth L.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 4 p. 807 - 814
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=0 - 20°C; 20 h;
参考文献
Kaul, Malvika; Mark, Lilly; Zhang, Yongzheng; Parhi, Ajit K.; Lavoie, Edmond J.; Pilch, Daniel S.
Biochemical Pharmacology, 2013 , vol. 86, # 12 p. 1699 - 1707
反应条件
thionyl chloride in benzene
2 h; Heating;
参考文献
NeuroMed Technologies Inc.
Patent: US2006/63775 A1, 2006 ;
Location in patent: Page/Page column 9; 11 ;
US 20060063775 A1
