6-溴-2H-苯并[b][1,4]噁嗪-4(3h)-羧酸叔丁酯合成路线 （共 5 条）
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in tetrahydrofuran
T=20°C;
参考文献
Curis, Inc.; Bao, Rudi; Lai, Chengjung; Qian, Changgeng
Patent: US2013/102595 A1, 2013 ;
Location in patent: Paragraph 0575 ;
反应条件
potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride in pentan-3-one
18 h; Heating / reflux;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2004/56820 A1, 2004 ;
Location in patent: Page 39 ;
反应条件
1.1: ethanol; tin(ll) chloride / 2 h / 70 °C
1.2: pH 7
2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C
4.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / tetrahydrofuran / 20 °C
View Scheme
参考文献
CURIS, INC.; BAO, Rudi; LAI, Chengjung; QIAN, Changgeng
Patent: WO2011/130628 A1, 2011 ;
WO 2011/130628 A1
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C
3: 4-(N,N-dimethlyamino)pyridine; triethylamine / tetrahydrofuran / 20 °C
View Scheme
参考文献
CURIS, INC.; BAO, Rudi; LAI, Chengjung; QIAN, Changgeng
Patent: WO2011/130628 A1, 2011 ;
WO 2011/130628 A1
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C
2: 4-(N,N-dimethlyamino)pyridine; triethylamine / tetrahydrofuran / 20 °C
View Scheme
参考文献
CURIS, INC.; BAO, Rudi; LAI, Chengjung; QIAN, Changgeng
Patent: WO2011/130628 A1, 2011 ;
WO 2011/130628 A1
