4,4-二甲基-2-(2-甲基苯基)-4,5-二氢-1,3-噁唑合成路线 （共 17 条）
反应条件
palladium diacetate; copper diacetate; p-benozquinone in acetonitrile
T=100°C; 41 h;
参考文献
Chen, Xiao; Li, Jiao-Jie; Hao, Xue-Shi; Goodhue, Charles E.; Yu, Jin-Quan
Journal of the American Chemical Society, 2006 , vol. 128, # 1 p. 78 - 79
反应条件
C2H3O2(1-)*C20H30OP(1-)*C20H31OP*Pd(2+); lithium tert-butylate in N,N-dimethyl acetamide
T=100°C; 14 h; Inert atmosphere;
参考文献
Ackermann, Lutz; Barfuesser, Sebastian; Kornhaass, Christoph; Kapdi, Anant R.
Organic Letters, 2011 , vol. 13, # 12 p. 3082 - 3085
反应条件
p-benozquinone in dichloromethane
T=100°C; 0.5 h;
参考文献
Chen, Xiao; Li, Jiao-Jie; Hao, Xue-Shi; Goodhue, Charles E.; Yu, Jin-Quan
Journal of the American Chemical Society, 2006 , vol. 128, # 1 p. 78 - 79
反应条件
thionyl chloride
1 h;
参考文献
Fu; Unruh; Miller; et al.
Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1259 - 1261
反应条件
1: 100 percent / CH2Cl2 / 0.5 h / 0 °C
2: 92 percent / thionyl chloride / 1 h
View Scheme
参考文献
Fu; Unruh; Miller; et al.
Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1259 - 1261
反应条件
1: 92 percent / thionyl chloride / 18 h / Ambient temperature
2: 100 percent / CH2Cl2 / 0.5 h / 0 °C
3: 92 percent / thionyl chloride / 1 h
View Scheme
参考文献
Fu; Unruh; Miller; et al.
Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1259 - 1261
反应条件
zinc(II) chloride
60 h; Irradiation;
参考文献
Clarke, David S.; Wood, Robin
Synthetic Communications, 1996 , vol. 26, # 7 p. 1335 - 1340
反应条件
palladium diacetate
1.) acetic acid, 2.) CH2Cl2, trifluoroacetic acid, 25 deg C, 24 h; Yield given. Multistep reaction;
参考文献
Clinet, J. C.; Balavoine, G.
Journal of Organometallic Chemistry, 1991 , vol. 405, # 2 p. C29 - C31
反应条件
n-butyllithium
1.) ethyl ether, 0 deg C, 1 h, 2.) RT, overnight; Yield given. Multistep reaction;
参考文献
Fu; Unruh; Miller; et al.
Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1259 - 1261
反应条件
1: 1.) n-BuLi / 1.) THF, from -40 to -10 deg C, 2.) THF, RT, 30 min
2: 86 percent / conc. aq. HCl / 24 h / Heating
View Scheme
参考文献
Griffiths, D. Vaughan; Griffiths, Penelope A.; Karim, Khalku; Whitehead, Belinda J.
Journal of Chemical Research, Miniprint, 1996 , # 4 p. 901 - 925
