5-氨基-1-(3-溴苯基)-1H-吡唑-4-甲腈合成路线 （共 6 条）
反应条件
in ethanol
1 h; Heating;
参考文献
Harden; Quinn; Scammells
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2892 - 2898
反应条件
1: 1.) NaNO2, HCl, 2.) SnCl2, HCl / 1.) H2O, 0 deg C, 2.) H2O, RT, 1 h
2: ethanol / Heating
View Scheme
参考文献
Harden; Quinn; Scammells
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2892 - 2898
反应条件
1: 1-(3-bromophenyl)hydrazine hydrochloride With sodium acetate in ethanol
0.5 h; Reflux;
2: (ethoxymethylene)malononitrile in ethanol
1 h; Reflux;
参考文献
Dos Santos, Mauricio S.; Oliveira, Mariana L.V.; Bernardino, Alice M.R.; De Leo, Rosa M.; Amaral, Veronica F.; De Carvalho, Flavia T.; Leon, Leonor L.; Canto-Cavalheiro, Marilene M.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 24 p. 7451 - 7454
参考文献
Harden; Quinn; Scammells
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2892 - 2898
反应条件
water
24 h; Heating;
参考文献
Peat, Andrew J.; Boucheron, Joyce A.; Dickerson, Scott H.; Garrido, Dulce; Mills, Wendy; Peckham, Jennifer; Preugschat, Frank; Smalley, Terrence; Schweiker, Stephanie L.; Wilson, Jayme R.; Wang, Tony Y.; Zhou, Huiqiang Q.; Thomson, Stephen A.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2121 - 2125
反应条件
1: H2O / 24 h / Heating
2: POCl3; DMF / 4 h / Heating
View Scheme
参考文献
Peat, Andrew J.; Boucheron, Joyce A.; Dickerson, Scott H.; Garrido, Dulce; Mills, Wendy; Peckham, Jennifer; Preugschat, Frank; Smalley, Terrence; Schweiker, Stephanie L.; Wilson, Jayme R.; Wang, Tony Y.; Zhou, Huiqiang Q.; Thomson, Stephen A.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2121 - 2125
