1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / ethylene glycol dimethyl ether; water / 5 h / 80 °C / Inert atmosphere 2: tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; bis[2-(diphenylphosphino)phenyl] ether / toluene / 15 h / 110 °C / Inert atmosphere 3: potassium tert-butylate / tetrahydrofuran / 8 h / 50 °C / Inert atmosphere View Scheme

diethyl ether; magnesium Behandeln des Reaktionsprodukts mit CO2;

1: (EtO)2P(O)CF2Br With zinc in isobutyramide T=50°C; 3 h; 2: With copper(I) bromide in isobutyramide 1 h; 3: 3-bromo-4-iodotoluene in isobutyramide T=20°C; 18 h;

1: (EtO)2P(O)CF2Br With zinc in isobutyramide T=45°C; 3 h; 2: With copper(I) bromide in isobutyramide T=20°C; 0.5 h; 3: 3-bromo-4-iodotoluene in isobutyramide T=20°C; 12 h; Sonication;