(1R,2S,5R)-(+)-5-甲基-2-(1-甲基-1-苯乙基)氯乙酸环己酯合成路线 （共 5 条）
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; samarium diiodide in tetrahydrofuran T=0°C; 0.5 h;
参考文献
Castagner, Bastien; Lacombe, Patrick; Ruel, Rejean
Journal of Organic Chemistry, 1998 , vol. 63, # 13 p. 4551 - 4553
反应条件
N,N-dimethyl-aniline in diethyl ether 1.) 0 deg C, 3 h, 2.) reflux, 3 h;
参考文献
Takagi, Ryukichi; Kimura, Jyunji; Shinohara, Yoshihiro; Ohba, Yuko; Takezono, Kyoko; Hiraga, Yoshikazu; Kojima, Satoshi; Ohkata, Katsuo
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 4 p. 689 - 698
反应条件
oxalyl dichloride; N,N-dimethyl-formamide 1.) CH3CN, -15 deg C, 30 min; 2.) room temp., 6 h; Yield given. Multistep reaction;
参考文献
Synthesis, , # 5 p. 420 - 421
反应条件
potassium hydroxide in ethanol Ambient temperature;
参考文献
Herzog, Heinz; Scharf, Hans-Dieter
Synthesis, 1986 , # 5 p. 420 - 421
反应条件
1: KOH / ethanol / Heating
2: TsOH / benzene / 80 °C
View Scheme
参考文献
Goodall, Karen; Parsons, Andrew F.
Tetrahedron Letters, 1997 , vol. 38, # 3 p. 491 - 494
