7-溴-5-甲基喹啉-8-醇合成路线 （共 3 条）
反应条件
1: 5,7-dibromo-8-hydroxy quinoline With sodium hydride in tetrahydrofuran
T=20°C; 2 h;
2: methyl iodide With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 2.25 h;
参考文献
SHIONOGI and CO., LTD.
Patent: EP1375486 A1, 2004 ;
Location in patent: Page 77; 78 ;
反应条件
bromine; tert-butylamine in chloroform; toluene
T=-78 - 20°C; 0.75 h;
参考文献
Zhuang, Linghang; Wai, John S.; Payne, Linda S.; Young, Steven D.; Fisher, Thorsten E.; Embrey, Mark W.; Guare, James P..
Patent: US2005/10048 A1, 2005 ;
Location in patent: Page/Page column 43 ;
反应条件
pyridine hydrochloride
T=220°C; 0.166667 h;
参考文献
Mongin, Florence; Mongin, Olivier; Trecourt, Francois; Godard, Alain; Queguiner, Guy
Tetrahedron Letters, 1996 , vol. 37, # 37 p. 6695 - 6698
