钠5-乙基-4,6-二氧代-1,4,5,6-四氢-2-嘧啶醇酸酯合成路线 （共 2 条）
反应条件
sodium in ethanol
T=40 - 100°C; 4.25 h; Inert atmosphere;
参考文献
F. HOFFMANN-LA-ROCHE AG; DOTSON, Jennafer; HEALD, Robert Andrew; HEFFRON, Timothy; JONES, Graham Elgin; KRINTEL, Sussie Lerche; MCLEAN, Neville James; NDUBAKU, Chudi; OLIVERO, Alan G.; SALPHATI, Laurent; WANG, Lan; WEI, BinQing
Patent: WO2012/82997 A1, 2012 ;
Location in patent: Page/Page column 83-84 ;
WO 2012/082997 A1
反应条件
trichlorophosphate
T=130 - 140°C; P=7500.75 - 9000.9 Torr; 0.5 h; Microwave irradiation;
参考文献
F. HOFFMANN-LA-ROCHE AG; DOTSON, Jennafer; HEALD, Robert Andrew; HEFFRON, Timothy; JONES, Graham Elgin; KRINTEL, Sussie Lerche; MCLEAN, Neville James; NDUBAKU, Chudi; OLIVERO, Alan G.; SALPHATI, Laurent; WANG, Lan; WEI, BinQing
Patent: WO2012/82997 A1, 2012 ;
Location in patent: Page/Page column 84 ;
WO 2012/082997 A1
