3-溴-5-(2-吡咯烷)吡啶合成路线 （共 12 条）
反应条件
sodium tetrahydroborate in methanol
参考文献
Bleicher, Leo S.; Cosford, Nicholas D. P.; Herbaut, Audrey; Stuart McCallum; McDonald, Ian A.
Journal of Organic Chemistry, 1998 , vol. 63, # 4 p. 1109 - 1118
反应条件
sodium borohydride; magnesium sulfate in methanol; water; acetic acid
参考文献
SIBIA Neurosciences, Inc.
Patent: US5703100 A1, 1997 ;
反应条件
1.1: sodium hydride / tetrahydrofuran / 1 h / Heating 1.2: 72 percent / aq. HCl / Heating 2.1: 81 percent / NaBH4 / methanol; acetic acid / -40 - 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 12 p. 4115 - 4121
反应条件
1.1: 94 percent / aq. H2SO4 / 18 h / Heating 2.1: sodium hydride / tetrahydrofuran / 1 h / Heating 2.2: 72 percent / aq. HCl / Heating 3.1: 81 percent / NaBH4 / methanol; acetic acid / -40 - 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 12 p. 4115 - 4121
反应条件
1: 71 percent / aq. HCl, charcoal / 1) 25 --> 98 deg C, 2 h; 2) 98 deg C, 2 h 2: 90 percent / sodium borohydride / methanol; acetic acid / 1) below -40 deg C, 1 h; 2) -40 deg C, 3 h; 3) 0 deg C, 18 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 4 p. 1109 - 1118
反应条件
2: Et3N / 10percent Pd/C / ethanol / 1 h / 760 Torr View Scheme
参考文献
Jacob III
Journal of Organic Chemistry, 1982 , vol. 47, # 21 p. 4165 - 4167
反应条件
hydrogen; triethylamine; palladium on activated charcoal in ethanol P=760.051 Torr;
参考文献
Isomura; Wirsching; Janda
Journal of Organic Chemistry, 2001 , vol. 66, # 12 p. 4115 - 4121
反应条件
1: 92 percent / formic acid / H2O / 18 h / 80 °C 2: 1.) K2CO3, copper(I) iodide, Ph3P / 1.) Pd/C / 1) DME, water, 25 deg C, 0.5 h; 2) DME, water, reflux, 16 h View Scheme
参考文献
Cosford; Bleicher; Herbaut; McCallum; Vernier J.-; Dawson; Whitten; Adams; Chavez-Noriega; Correa; Crona; Mahaffy; Menzaghi; Rao; Reid; Sacaan; Santori; Stauderman; Whelan; et
Journal of Medicinal Chemistry, 1996 , vol. 39, # 17 p. 3235 - 3237
参考文献
McIntee, Edward J.; Hecht, Stephen S.
Chemical Research in Toxicology, 2000 , vol. 13, # 3 p. 192 - 199
参考文献
Bleicher, Leo S.; Cosford, Nicholas D. P.; Herbaut, Audrey; Stuart McCallum; McDonald, Ian A.
Journal of Organic Chemistry, 1998 , vol. 63, # 4 p. 1109 - 1118
