3,5-二甲氧基苯基丙酸合成路线 （共 20 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol; ethyl acetate P=1551.49 - 2068.65 Torr; 5 h;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2007/71348 A1, 2007 ;
Location in patent: Page/Page column 87 ;
反应条件
hydrogen; palladium 10 on activated carbon in ethanol 16 h;
参考文献
BAYER PHARMACEUTICALS CORPORATION
Patent: WO2004/11446 A1, 2004 ;
Location in patent: Page 72 ;
反应条件
1: piperidinium acetate; NaBH3CN / ethanol / 20 °C 2: TfOH / 1,2-dichloro-ethane / 2.75 h / Heating View Scheme
参考文献
Organic Letters, , vol. 5, # 24 p. 4653 - 4656
反应条件
trifluorormethanesulfonic acid in 1,2-dichloro-ethane Friedel-Crafts acylation; 2.75 h; Heating;
参考文献
Fillion, Eric; Fishlock, Dan
Organic Letters, 2003 , vol. 5, # 24 p. 4653 - 4656
反应条件
water in acetonitrile T=120°C; 0.5 h; microwave irradiation;
参考文献
Tetrahedron, , vol. 63, # 2 p. 389 - 395
反应条件
sodium ethanolate Erhitzen des Reaktionsprodukts auf 150grad;
参考文献
Journal of the American Chemical Society, , vol. 79, p. 3114,3117
反应条件
sodium hydroxide 12 h; Heating;
参考文献
Synthetic Communications, , vol. 14, # 7 p. 599 - 604
反应条件
1: 1.) HONO, 2.) CuBr / 1.) aq. acetone, 0 deg C 2: 1.)Zn, 2.) H2= / 1.) THF 3: aq. NaOH / 12 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 14, # 7 p. 599 - 604
反应条件
1: 1.)Zn, 2.) H2= / 1.) THF 2: aq. NaOH / 12 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 14, # 7 p. 599 - 604
反应条件
1: sodium amalgam; alkali 2: alkali View Scheme
参考文献
Journal of the Chemical Society, , vol. 97, p. 2417
