2,3-二甲氧基苯甲酰氯合成路线 （共 40 条）
反应条件
1: ammonium hydroxide / dichloromethane; water / 0.5 h / -5 - 35 °C 2: trichlorophosphate / toluene / 30 - 85 °C View Scheme
参考文献
LAURUS LABS PRIVATE LIMITED; MUDDULURU, Hari Krishna; MADHAVARAM, Shankar
Patent: WO2014/13512 A1, 2014 ;
反应条件
Pd-BaSO4; xylene T=140°C; Hydrogenation;
参考文献
Mauthner
Journal fuer Praktische Chemie (Leipzig), 1926 , vol. <2> 112, p. 63
反应条件
T=140°C; Hydrogenation;
参考文献
Mauthner
Journal fuer Praktische Chemie (Leipzig), 1926 , vol. <2> 112, p. 63
反应条件
1: ammonium hydroxide / dichloromethane; water / 0.5 h / -5 - 35 °C 2: trichlorophosphate / toluene / 30 - 85 °C 3: triethylamine; AlCl3, aluminium chloride / toluene / 9.5 h / 30 - 75 °C 4: water; hydrogenchloride / toluene / 0.5 h / 15 - 35 °C View Scheme
参考文献
LAURUS LABS PRIVATE LIMITED; MUDDULURU, Hari Krishna; MADHAVARAM, Shankar
Patent: WO2014/13512 A1, 2014 ;
反应条件
1.1: sodium azide / acetone; H2O / 1 h / 15 °C 2.1: benzene / 2 h / 60 °C 2.2: conc. HCl / 18 h / 80 °C View Scheme
参考文献
Stuart; Khora; McKenney Jr.; Castle
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 6 p. 1589 - 1594
反应条件
1: beim Erwaermen des erhaltenen Reaktionsprodukts mit Essigsaeure,HCl und H2O 2: HBr; acetic acid View Scheme
参考文献
Horton; Spence
Journal of the American Chemical Society, 1955 , vol. 77, p. 2894
反应条件
1: ammonium hydroxide / dichloromethane; water / 0.5 h / -5 - 35 °C 2: trichlorophosphate / toluene / 30 - 85 °C 3: triethylamine; AlCl3, aluminium chloride / toluene / 9.5 h / 30 - 75 °C View Scheme
参考文献
LAURUS LABS PRIVATE LIMITED; MUDDULURU, Hari Krishna; MADHAVARAM, Shankar
Patent: WO2014/13512 A1, 2014 ;
反应条件
1: NaOAc / acetic acid / 20 °C View Scheme
参考文献
Synlett, , # 3 p. 501 - 503
参考文献
McCabe et al.
Journal of Organic Chemistry, 1954 , vol. 19, p. 493,496
反应条件
1: 72 percent / AlCl3 / benzene / 20 h / Ambient temperature 2: 90.5 percent / pyridine, tetramethylammoniumhydroxid / H2O / 24 h / Heating View Scheme
参考文献
Mahfouz; Hambloch; Omar; Frahm
Archiv der Pharmazie, 1990 , vol. 323, # 3 p. 163 - 169
